Singh Kulwant, Sethi Jasmine, Duggal Rajan, Joshi Kusum, Bains Arjinder S
Division of Nephrology, Grecian Hospital, Mohali, Punjab, India.
Department of Histopathology, Core Diagnostics, Gurgaon, Haryana, India.
Indian J Nephrol. 2020 May-Jun;30(3):204-206. doi: 10.4103/ijn.IJN_258_19. Epub 2020 Feb 11.
Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. Amyloidosis derived from leukocyte cell-derived chemotaxin 2 (LECT2) is a recently recognized form of amyloidosis in the United States with predominant involvement of kidney and liver. We present a case of ALECT2 renal amyloid in a transplant recipient who presented with gradual worsening of graft function and subnephrotic proteinuria. To our knowledge, this is first case of LECT2 amyloidosis from Northern India in a transplant recipient. There is no effective therapy for amyloidosis derived from leukocyte cell-derived chemotaxin 2.
淀粉样变性的特征是异常蛋白质聚集体在各种组织中病理性沉积，其中AL蛋白最为常见。源自白细胞衍生趋化因子2（LECT2）的淀粉样变性是美国最近认识到的一种淀粉样变性形式，主要累及肾脏和肝脏。我们报告了一例移植受者的ALECT2肾淀粉样变性病例，该患者移植肾功能逐渐恶化并出现亚肾病性蛋白尿。据我们所知，这是印度北部移植受者中首例LECT2淀粉样变性病例。目前尚无针对白细胞衍生趋化因子2所致淀粉样变性的有效治疗方法。
