Novel Alkyl(aryl)-Substituted 2,2-Difluoro-6-(trichloromethyl)-2-1,3,2-oxazaborinin-3-ium-2-uides: Synthesis, Antimicrobial Activity, and CT-DNA Binding Evaluations.

The synthesis, antimicrobial activity evaluations, biomolecule-binding properties (DNA), and absorption and emission properties of a new series of ()-1,1,1-trichloro-4-alkyl(aryl)amino-4-arylbut-3-en-2-ones and 2,2-difluoro-3-alkyl(aryl)amino-4-aryl-6-(trichloromethyl)-2-1,3,2-oxazaborinin-3-ium-2-uides in which 3(4)-alkyl(aryl) = H, Me, -propyl, -butyl, CH, 4-CHCH, 4-CHOCH, 4-NOCH, 4-FCH, 4-BrCH, 2-naphthyl, is reported. A series of β-enaminoketones is synthesized from the O,N-exchange reaction of some amines with ()-1,1,1-trichloro-4-methoxy-4-aryl-but-3-en-2-ones at 61-90% yields. Subsequently, reactions of the resulting β-enaminoketones with an appropriate source of boron (BF.OEt) gave the corresponding oxazaborinine derivatives at 50-91% yields. UV-Vis and emission properties of biomolecule-binding properties for the DNA of these new BF-β-enamino containing CCl units were also evaluated. Some compounds from the present series also exhibited potent antimicrobial effects on various pathogenic microorganisms at concentrations below those that showed cytotoxic effects. Compounds , and showed the best results and are very significant against , which causes diseases in humans and animals.