Zhou Zhihuan, Gao Ning, Wang Yumeng, Chang Pengcheng, Tong Yi, Fu Shufei
College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Pharmacol. 2020 Sep 10;11:560448. doi: 10.3389/fphar.2020.560448. eCollection 2020.
This study aims to analyze the current situation and characteristics of traditional Chinese medicine for treatment of novel coronavirus pneumonia, clarify its clinical advantages and provide a reference for clinical treatment.
Clinical randomized controlled trials, clinical control trials and case series research involving the use of Chinese medicine for novel coronavirus pneumonia treatment were selected from PubMed, Chinese Journal Service Platform of CNKI, VIP, and WanFang Data Knowledge Service Platform from the establishment of the library to 11:00 am on April 15, 2020. The published information, research design, intervention measures and research observation index were statistically analyzed.
Twenty studies were included. The research methods were mainly clinical controlled trials. The observation indicators were mostly fever improvement time, cough improvement time, shortness of breath improvement time, chest CT and CRP examination. Maxing Ganshi (, and ) decoction was the core prescription. The most frequently used drugs were (Gancao) (Mahuang) (Kuxingren) (Cangzhu), and (Huangqin). The most frequently used drug combination was (Mahuang)- (Kuxingren). The most frequently used Chinese patent medicine was Lianhua Qingwen capsule/granule.
Traditional Chinese medicine has widely used for novel coronavirus pneumonia in China. It is worthy of global attention. Also, high-quality randomized controlled clinical trials on the effectiveness and safety of traditional Chinese medicine in the treatment of novel coronavirus pneumonia need to carry out.
本研究旨在分析中医药治疗新型冠状病毒肺炎的现状与特点，阐明其临床优势，为临床治疗提供参考。
从PubMed、中国知网中文期刊服务平台、维普、万方数据知识服务平台建库至2020年4月15日上午11:00，筛选涉及使用中医药治疗新型冠状病毒肺炎的临床随机对照试验、临床对照试验和病例系列研究。对发表的信息、研究设计、干预措施和研究观察指标进行统计分析。
纳入20项研究。研究方法主要为临床对照试验。观察指标多为发热改善时间、咳嗽改善时间、气短改善时间、胸部CT及CRP检查。麻杏甘石汤为核心方剂。最常用药物为甘草、麻黄、苦杏仁、苍术、黄芩。最常用药物组合为麻黄-苦杏仁。最常用中成药为连花清瘟胶囊/颗粒。
中医药在中国已广泛用于新型冠状病毒肺炎的治疗。值得全球关注。此外，还需开展关于中医药治疗新型冠状病毒肺炎有效性和安全性的高质量随机对照临床试验。
