Rettig R, Ganten D, Lang R E, Unger T
Eur Heart J. 1987 May;8 Suppl B:129-32. doi: 10.1093/eurheartj/8.suppl_b.129.
The results of biochemical, immunohistochemical and autoradiographic studies led to the description of the endogenous brain angiotensin II system as a highly localized network of angiotensin II-containing cell bodies and fibres as well as characteristic sites with high angiotensin II-receptor density. The specific localization of this system predominantly within limbic, hypothalamic and brain stem structures that are known to be involved in central cardiovascular regulation and the control of volume homeostasis, suggests a possible functional role for brain angiotensin II in the control of these homeostatic functions. A role for brain angiotensin II in the central control of blood pressure is further supported by physiological and pharmacological experiments that demonstrate characteristic central angiotensin-induced cardiovascular responses. However, it should be kept in mind that the mechanisms mediating these responses (e.g. sympathetic activation, vasopressin release), as well as the exact functional role of endogenously synthesized angiotensin II in specific brain areas, are not yet completely understood. Pathophysiologically, there is evidence that an activated brain renin angiotensin system may participate in the development and maintenance of primary hypertension.
生化、免疫组织化学和放射自显影研究结果表明，内源性脑肾素血管紧张素系统是一个高度局部化的网络，由含血管紧张素II的细胞体和纤维以及血管紧张素II受体密度高的特征性位点组成。该系统主要定位于已知参与中枢心血管调节和容量稳态控制的边缘系统、下丘脑和脑干结构内，这表明脑内血管紧张素II在控制这些稳态功能中可能具有功能性作用。生理和药理实验进一步证明了脑内血管紧张素II在血压中枢控制中的作用，这些实验显示了血管紧张素诱导的典型中枢心血管反应。然而，应牢记介导这些反应的机制（如交感神经激活、血管加压素释放）以及内源性合成的血管紧张素II在特定脑区的确切功能作用尚未完全明确。在病理生理学方面，有证据表明激活的脑肾素血管紧张素系统可能参与原发性高血压的发生和维持。
