黏菌素对中国监测项目中当代（2015 - 2017年）分离株的抗菌活性。
Antimicrobial Activity of Colistin Against Contemporary (2015 - 2017) and Isolates From a Chinese Surveillance Program.
作者信息
Zhang Hui, Zhang Ge, Zhang Jingjia, Duan Simeng, Kang Yue, Yang Qiwen, Xu Yingchun
机构信息
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
MRL Global Medical Affairs, MSD China, Shanghai, China.
出版信息
Front Microbiol. 2020 Sep 4;11:1966. doi: 10.3389/fmicb.2020.01966. eCollection 2020.
OBJECTIVE
To investigate the incidence and susceptibilities of non-fermenting bacteria isolates from Chinese respiratory (RTI), intra-abdominal (IAI) and urinary tract (UTI) infections to antimicrobial agents between 2015 and 2017.
METHODS
In total, 3,246 non-fermentative bacteria were collected from 21 hospitals and 9 hospital departments across 7 regions of China. A central testing laboratory was employed to determine antimicrobial susceptibilities using appropriate standards of interpretation.
RESULTS
The majority of the isolates were ( = 1,360, 41.9%) and ( = 1,341, 41.3%). Overall multidrug resistance (MDR) and carbapenem resistance (CR) rates of were 80.1 and 78.7% with MDR and CR rates in RTIs, IAIs, and UTIs of 82.0 and 81.0%, 82.6 and 81.0% as well as 53.1 and 46.9%. Overall MDR and CR rates of isolates were 36.2 and 38.9% with 41.8 and 44.3%, 29.3 and 36.1% as well as 24.2 and 20.2% MDR and CR rates in RTIs, IAIs, and UTIs. Overall susceptibility rates to imipenem, meropenem, amikacin, ciprofloxacin, cefepime and piperacillin-tazobactam were 21.1, 21.3, 33.0, 18.4, 19.2, and 19.6% for and 56.5, 58.5, 88.4, 63.1, 63.1, and 55.63% for isolates, whereas for colistin they were 95.7 and 94.6%, respectively. In all departments and regions of China, susceptibility rates of and isolates to colistin were constantly above 80%.
CONCLUSION
Due to the high MDR and CR rates for and , isolates obtained from RTIs, IAIs, and UTIs only maintained high susceptibility rates to colistin between 2015 and 2017.
目的
调查2015年至2017年期间从中国呼吸道感染（RTI）、腹腔内感染（IAI）和尿路感染（UTI）患者中分离出的非发酵菌的发生率及其对抗菌药物的敏感性。
方法
从中国7个地区的21家医院和9个医院科室共收集了3246株非发酵菌。由一个中央检测实验室采用适当的解释标准来确定抗菌药物敏感性。
结果
大多数分离株为[具体菌名1]（n = 1360，41.9%）和[具体菌名2]（n = 1341，41.3%）。[具体菌名1]的总体多重耐药（MDR）率和碳青霉烯耐药（CR）率分别为80.1%和78.7%，其中RTI、IAI和UTI中的MDR率和CR率分别为82.0%和81.0%、82.6%和81.0%以及53.1%和46.9%。[具体菌名2]分离株的总体MDR率和CR率分别为36.2%和38.9%，RTI、IAI和UTI中的MDR率和CR率分别为41.8%和44.3%、29.3%和36.1%以及24.2%和20.2%。[具体菌名1]分离株对亚胺培南、美罗培南、阿米卡星、环丙沙星、头孢吡肟和哌拉西林-他唑巴坦的总体敏感率分别为21.1%、21.3%、33.0%、18.4%、19.2%和19.6%，[具体菌名2]分离株的相应敏感率分别为56.5%、58.5%、88.4%、63.1%、63.1%和55.63%，而对黏菌素的敏感率分别为95.7%和94.6%。在中国所有科室和地区，[具体菌名1]和[具体菌名2]分离株对黏菌素的敏感率始终高于80%。
结论
由于[具体菌名1]和[具体菌名2]的MDR率和CR率较高，2015年至2017年期间从RTI、IAI和UTI患者中分离出的这两种菌仅对黏菌素保持较高的敏感率。
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