Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Front Immunol. 2020 Sep 11;11:1746. doi: 10.3389/fimmu.2020.01746. eCollection 2020.
Innate immune memory is a part of the innate immune system that facilitates the elimination of pathogens. However, it may exacerbate neuropathology. In this study, we found that innate immune memory is detrimental in stroke, because it promotes the acute immune response and exacerbates ischemic infarcts. Mesenchymal stem cell therapy has been widely studied for its therapeutic potential in various diseases including stroke, but whether it diminishes innate immune memory has not been studied. Here, our study demonstrates that, after the activation of innate immune memory by lipopolysaccharide, mesenchymal stem cell therapy can diminish innate immune memory though down-regulation of H3 methylation and subsequently protect against stroke. Our results demonstrate that innate immune memory is detrimental in stroke, and we describe a novel potential therapeutic target involving the use of mesenchymal stem cells to treat stroke patients.
先天免疫记忆是先天免疫系统的一部分，有助于消除病原体。然而，它可能会加重神经病理学。在这项研究中，我们发现先天免疫记忆对中风是有害的，因为它促进了急性免疫反应并加重了缺血性梗死。间充质干细胞治疗因其在包括中风在内的各种疾病中的治疗潜力而被广泛研究，但它是否能减弱先天免疫记忆尚未得到研究。在这里，我们的研究表明，在脂多糖激活先天免疫记忆后，间充质干细胞治疗可以通过下调 H3 甲基化来减弱先天免疫记忆，从而预防中风。我们的结果表明，先天免疫记忆对中风是有害的，我们描述了一个新的潜在治疗靶点，涉及使用间充质干细胞来治疗中风患者。
