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白细胞介素24 mRNA水平在头颈部鳞状细胞癌及其亚组中的临床意义：一项计算机模拟研究

Clinical Significance of the Interleukin 24 mRNA Level in Head and Neck Squamous Cell Carcinoma and Its Subgroups: An In Silico Investigation.

作者信息

Qiu Lan-Lan, Zhang Xiao-Guohui, Chen Gang, Dang Yi-Wu, Huang Zhi-Guang, Li Ming-Xuan, Liang Yao, Huang Su-Ning, Tang Xiao-Zhun, Chen Xiao-Xia, Wei Hong-Yu, Wu Hua-Yu

机构信息

Department of Cell Biology and Genetics, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.

Department of Pathophysiology, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.

出版信息

J Oncol. 2020 Sep 18;2020:7042025. doi: 10.1155/2020/7042025. eCollection 2020.

DOI:10.1155/2020/7042025
PMID:33014054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7519990/
Abstract

IL24 mRNA is known to have an apoptotic effect on cancer cells but not on noncancer cells. However, the expression level of the IL24 mRNA in head and neck squamous cell carcinoma (HNSCC) and its subgroups is rarely studied. In this study, the clinical implication of IL24 mRNA was evaluated in the common subgroups of HNSCC, including oral squamous cell carcinoma (OSCC), nasopharyngeal carcinoma (NPC), and laryngeal squamous cell carcinoma (LSCC) for analysis. Substantial IL24 mRNA expression data were calculated from several databases, such as the Gene Expression Omnibus (GEO), ArrayExpress, Sequence Read Archive (SRA), ONCOMINE, and The Cancer Genome Atlas (TCGA) databases. We ultimately collected a total of 41 microarrays and RNA-seq including 1,564 HNSCC and 603 noncancer tissue samples. IL24 mRNA was highly expressed in OSCC, LSCC, and NPC as shown by the separated standard mean difference (SMD), as well as HNSCC as a whole part (SMD = 1.47, 95% confdence interval (CI) = 1.24-1.70, < 0.0001). In all subgroups, the IL24 mRNA upregulation had the ability to distinguish cancer from noncancer tissue with area under the curves (AUCs) of the summary receiver operating characteristic (sROC) higher than 0.85. In conclusion, IL24 mRNA may be used as a potential marker for cancer screening, and its clinical diagnostic value needs to be further studied. It also provides a new idea for the treatment of the IL24 gene in HNSCC and its subgroups in the future.

摘要

已知白细胞介素24（IL24）信使核糖核酸（mRNA）对癌细胞有凋亡作用，但对非癌细胞无此作用。然而，头颈部鳞状细胞癌（HNSCC）及其亚组中IL24 mRNA的表达水平鲜有研究。在本研究中，对HNSCC的常见亚组，包括口腔鳞状细胞癌（OSCC）、鼻咽癌（NPC）和喉鳞状细胞癌（LSCC）进行分析，以评估IL24 mRNA的临床意义。从多个数据库，如基因表达综合数据库（GEO）、ArrayExpress、序列读取存档库（SRA）、ONCOMINE和癌症基因组图谱（TCGA）数据库中计算出大量IL24 mRNA表达数据。我们最终共收集了41个微阵列和RNA测序数据，包括1564份HNSCC和603份非癌组织样本。如独立标准平均差（SMD）所示，IL24 mRNA在OSCC、LSCC和NPC中高表达，在整个HNSCC中也是如此（SMD = 1.47，95%置信区间（CI）= 1.24 - 1.70，P < 0.0001）。在所有亚组中，IL24 mRNA上调能够区分癌组织和非癌组织，汇总受试者工作特征曲线（sROC）的曲线下面积（AUC）高于0.85。总之，IL24 mRNA可能用作癌症筛查的潜在标志物，其临床诊断价值有待进一步研究。这也为未来HNSCC及其亚组中IL24基因的治疗提供了新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/216854acad34/JO2020-7042025.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/01a3cf21f307/JO2020-7042025.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/216854acad34/JO2020-7042025.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/01a3cf21f307/JO2020-7042025.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/9d4d74024b24/JO2020-7042025.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/12b18b517bf3/JO2020-7042025.003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4a1/7519990/216854acad34/JO2020-7042025.007.jpg

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