Ogun Gabriel Olabiyi, Ezenkwa Uchenna Simon, Ayandipo Omobolaji Oladayo
Department of Pathology, University of Ibadan/University College Hospital, Ibadan, 200001, Nigeria.
https://orcid.org/0000-0001-8535-3240.
Ecancermedicalscience. 2020 Aug 7;14:1086. doi: 10.3332/ecancer.2020.1086. eCollection 2020.
Dermatofibrosarcoma protuberance (DFSP) is the commonest, yet rare, dermal sarcoma globally. There are few reports in the literature of this neoplasm in Nigerians and indeed in sub-Saharan Africa. This study documents our institutional practice observation and compares it with those from other regions of the world.
This study was a retrospective review of all cases of histologically diagnosed DFSP at the University College Hospital, Ibadan, Nigeria, spanning a period of 27 years (January 1989-December 2016). Data on patient age, gender, tumour location, size, tumour recurrence and metastasis status were obtained from clinical and surgical pathology archival files and records.
Sixty-nine cases of DFSP were recorded over the period reviewed with a male-female ratio of 1.6:1. The mean age of the study population was 39.6 years. The youngest patient was 5-year old, while the oldest was 86 years and the modal age group was the 4th decade. The trunk was the commonest anatomic tumour location. Recurrences were seen in seven cases with recurrence interval ranging from 6 to 240 months. The correlation between tumour size and age was non-significant ( = -0.183; = 0.182). There was fibrosarcoma-like transformation in three cases (4.3%) studied.
Dermatofibrosarcoma protuberance is rare in our population and occurs more commonly in males and on the trunk. Recurrence can occur beyond the recommended follow-up period of 10 years.
隆突性皮肤纤维肉瘤（DFSP）是全球最常见但却罕见的皮肤肉瘤。关于尼日利亚人乃至撒哈拉以南非洲地区这种肿瘤的文献报道很少。本研究记录了我们机构的实际观察情况，并将其与世界其他地区的情况进行比较。
本研究是对尼日利亚伊巴丹大学学院医院27年（1989年1月至2016年12月）期间所有经组织学诊断为DFSP的病例进行的回顾性研究。从临床和外科病理档案及记录中获取患者年龄、性别、肿瘤位置、大小、肿瘤复发和转移状况的数据。
在回顾期间共记录了69例DFSP病例，男女比例为1.6:1。研究人群的平均年龄为39.6岁。最年轻的患者为5岁，最年长的为86岁，发病高峰年龄组为第四十年龄段。躯干是最常见的肿瘤解剖位置。7例出现复发，复发间隔时间为6至240个月。肿瘤大小与年龄之间的相关性不显著（ = -0.183； = 0.182）。在研究的3例（4.3%）病例中出现了纤维肉瘤样转化。
隆突性皮肤纤维肉瘤在我们的人群中很罕见，在男性和躯干上更常见。复发可能发生在推荐的10年随访期之后。
