Albert J L, Kubik C J, Archer D F
Fertil Steril. 1987 Aug;48(2):198-203. doi: 10.1016/s0015-0282(16)59342-x.
Pituitary luteinizing hormone (LH) pulse frequency and amplitude were assessed as an indirect indicator of hypothalamic luteinizing hormone-releasing hormone (LH-RH) release in women with evidence of ovarian failure. Exogenous LH-RH (20 micrograms) was administered intravenously every 2 hours for 48 hours to determine the effect on pituitary LH release and the hypothalamic pulse generator for LH-RH secretion. This study design was used to investigate the possibility of an ultrashort negative feedback of LH-RH upon the synthesis and release of endogenous LH-RH. A wide range of LH pulse frequencies (8 to 28 pulses/24 hours) was present in these women. There was no discernible inhibition of hypothalamic LH-RH pulse frequency during or following exogenous LH-RH administration. Mean peripheral LH levels were significantly increased during exogenous LH-RH administration (P = 0.0038), reflecting both an increased baseline and an augmented pituitary LH response to the exogenous LH-RH. There were no differences found in LH pulse amplitude before and after LH-RH treatment. These data indicate that pituitary LH secretion in women with ovarian failure can be further stimulated by exogenous LH-RH. However, there was no evidence for inhibition of either pituitary LH secretion or hypothalamic LH-RH release using this administration schedule of exogenous LH-RH.
对于有卵巢功能衰竭证据的女性，评估垂体促黄体生成素（LH）的脉冲频率和幅度，作为下丘脑促黄体生成素释放激素（LH-RH）释放的间接指标。每2小时静脉注射外源性LH-RH（20微克），持续48小时，以确定其对垂体LH释放和下丘脑LH-RH分泌脉冲发生器的影响。本研究设计用于调查LH-RH对内源性LH-RH合成和释放的超短负反馈的可能性。这些女性存在广泛的LH脉冲频率范围（8至28次脉冲/24小时）。在外源性LH-RH给药期间或之后，未观察到下丘脑LH-RH脉冲频率有明显抑制。在外源性LH-RH给药期间，外周平均LH水平显著升高（P = 0.0038），这既反映了基线升高，也反映了垂体LH对外源性LH-RH的反应增强。LH-RH治疗前后的LH脉冲幅度未发现差异。这些数据表明，外源性LH-RH可进一步刺激卵巢功能衰竭女性的垂体LH分泌。然而，使用这种外源性LH-RH给药方案，没有证据表明垂体LH分泌或下丘脑LH-RH释放受到抑制。
