1例以钠-葡萄糖协同转运蛋白2抑制剂作为应激性心肌病和心力衰竭促成因素的病例。

A case in which SGLT2 inhibitor is a contributing factor to takotsubo cardiomyopathy and heart failure.

作者信息

Kinoshita Haruyuki, Sugino Hiroshi, Oka Toshiharu, Ichikawa Orie, Shimonaga Takashi, Sumimoto Yoji, Kashiwabara Ayano, Sakai Takumi

机构信息

Division of Cardiology National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.

出版信息

J Cardiol Cases. 2020 Jul 2;22(4):177-180. doi: 10.1016/j.jccase.2020.06.014. eCollection 2020 Oct.

DOI:10.1016/j.jccase.2020.06.014

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7520524/

Abstract

SGLT2 inhibitors are reported to have advantages in protecting against heart failure events. However, there are also reports of concerns when given to older persons or persons with geriatric syndrome. Our case is an example of a patient with a history of chronic thyroiditis where the SGLT2 inhibitor triggered a thyroid crisis, and blood catecholamine overload caused takotsubo cardiomyopathy and heart failure. < SGLT2 inhibitor is a type of medicine for diabetes that has been used frequently. But if we are not careful about underlying disease and clinical course, it might lead to exacerbation of heart failure.>.

摘要

据报道，钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂在预防心力衰竭事件方面具有优势。然而，也有报告称，在给老年人或患有老年综合征的人使用时会出现问题。我们的病例是一名有慢性甲状腺炎病史的患者，SGLT2抑制剂引发了甲状腺危象，血液中儿茶酚胺过载导致了应激性心肌病和心力衰竭。<SGLT2抑制剂是一种常用的糖尿病药物。但如果我们对潜在疾病和临床过程不谨慎，可能会导致心力衰竭加重。>

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本文引用的文献

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Thyroid Storm and Diabetic Ketoacidosis Presenting to the Emergency Department.甲状腺危象与糖尿病酮症酸中毒患者就诊于急诊科。

Cureus. 2020 Jan 23;12(1):e6751. doi: 10.7759/cureus.6751.

2

Recommendations on the proper use of SGLT2 inhibitors.关于钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂正确使用的建议。

Diabetol Int. 2019 Nov 15;11(1):1-5. doi: 10.1007/s13340-019-00415-8. eCollection 2020 Jan.

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A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF).一项评估钠-葡萄糖协同转运蛋白 2 抑制剂达格列净对射血分数降低的心力衰竭患者发病率和死亡率影响的试验（DAPA-HF）。

Eur J Heart Fail. 2019 May;21(5):665-675. doi: 10.1002/ejhf.1432. Epub 2019 Mar 21.

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Stress-related cardiomyopathy syndromes.应激性心肌病综合征

Circulation. 2008 Jul 22;118(4):397-409. doi: 10.1161/CIRCULATIONAHA.106.677625.

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Management of thyrotoxicosis.甲状腺毒症的管理。

South Med J. 2002 May;95(5):493-505.

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[Painless (silent) thyroiditis].

Nihon Rinsho. 1999 Aug;57(8):1770-4.

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Med Clin North Am. 1995 Jan;79(1):169-84. doi: 10.1016/s0025-7125(16)30090-6.

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