Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Oxid Med Cell Longev. 2020 Sep 14;2020:6095673. doi: 10.1155/2020/6095673. eCollection 2020.
Redox homeostasis is regulated by critical molecules that modulate antioxidant and redox signaling (ARS) within the cell. Imbalances among these molecules can lead to oxidative stress and damage to cell functions, causing a variety of diseases. Brahma-related gene 1 (BRG1), also known as SMARCA4, is the central ATPase catalytic subunit of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, which plays a core role in DNA replication, repair, recombination, and transcriptional regulation. Numerous recent studies show that BRG1 is involved in the regulation of various cellular processes associated with ARS. BRG1, as a major factor in chromatin remodeling, is essential for the repair of oxidative stress-induced DNA damage and the activation of antioxidant genes under oxidative stress. Consequently, a comprehensive understanding of the roles of BRG1 in redox homeostasis is crucial to understand the normal functioning as well as pathological mechanisms. In this review, we summarized and discussed the role of BRG1 in the regulation of ARS.
氧化还原稳态由关键分子调节，这些分子在细胞内调节抗氧化和氧化还原信号（ARS）。这些分子之间的不平衡可能导致氧化应激和细胞功能损伤，导致多种疾病。Brahma 相关基因 1（BRG1），也称为 SMARCA4，是开关/蔗糖不可发酵（SWI/SNF）染色质重塑复合物的中央 ATP 酶催化亚基，在 DNA 复制、修复、重组和转录调控中发挥核心作用。最近的许多研究表明，BRG1 参与调节与 ARS 相关的各种细胞过程。BRG1 作为染色质重塑的主要因素，对于修复氧化应激诱导的 DNA 损伤以及在氧化应激下抗氧化基因的激活至关重要。因此，全面了解 BRG1 在氧化还原稳态中的作用对于理解正常功能以及病理机制至关重要。在这篇综述中，我们总结和讨论了 BRG1 在 ARS 调节中的作用。
