Firth Jahn M, Yang Hsiang-Yu, Francis Alice J, Islam Najah, MacLeod Kenneth T
National Heart and Lung Institute, Imperial College, Hammersmith Hospital, London, United Kingdom.
Cardiovascular Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (R.O.C.).
JACC Basic Transl Sci. 2020 Sep 2;5(9):901-912. doi: 10.1016/j.jacbts.2020.06.013. eCollection 2020 Sep.
Contradictory findings of estrogen supplementation in cardiac disease highlight the need to investigate the involvement of estrogen in the progression of heart failure in an animal model that lacks traditional comorbidities. Heart failure was induced by aortic constriction (AC) in female guinea pigs. Selected AC animals were ovariectomized (ACOV), and a group of these received 17β-estradiol supplementation (ACOV+E). One hundred-fifty days post-AC surgery, left-ventricular myocytes were isolated, and their electrophysiology and Ca and Na regulation were examined. Long-term absence of ovarian hormones exacerbates the decline in cardiac function during the progression to heart failure. Estrogen supplementation reverses these aggravating effects.
雌激素补充疗法在心脏病治疗中的矛盾结果凸显了在缺乏传统合并症的动物模型中研究雌激素在心力衰竭进展过程中所起作用的必要性。通过对雌性豚鼠进行主动脉缩窄（AC）来诱发心力衰竭。选择接受AC手术的动物进行卵巢切除术（ACOV），其中一组接受17β-雌二醇补充治疗（ACOV+E）。AC手术后150天，分离左心室肌细胞，并检测其电生理学以及钙和钠调节情况。长期缺乏卵巢激素会加剧心力衰竭进展过程中心脏功能的下降。补充雌激素可逆转这些加剧作用。
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