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Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19.

作者信息

Bovijn Jonas, Lindgren Cecilia M, Holmes Michael V

机构信息

Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.

Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

出版信息

Lancet Rheumatol. 2020 Nov;2(11):e658-e659. doi: 10.1016/S2665-9913(20)30345-3. Epub 2020 Sep 25.

DOI:10.1016/S2665-9913(20)30345-3
PMID:33015641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7518829/
Abstract
摘要

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本文引用的文献

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Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study.重症监护病房中新冠肺炎患者使用托珠单抗的多中心观察性研究。
Lancet Rheumatol. 2020 Oct;2(10):e603-e612. doi: 10.1016/S2665-9913(20)30277-0. Epub 2020 Aug 14.
2
The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic.新冠病毒宿主遗传学计划，一项旨在阐明宿主遗传因素在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒大流行的易感性和严重性中所起作用的全球倡议。
Eur J Hum Genet. 2020 Jun;28(6):715-718. doi: 10.1038/s41431-020-0636-6. Epub 2020 May 13.
3
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study.白细胞介素-6信号传导对缺血性中风及其他心血管结局的影响：一项孟德尔随机化研究
Circ Genom Precis Med. 2020 Jun;13(3):e002872. doi: 10.1161/CIRCGEN.119.002872. Epub 2020 May 12.
4
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.白细胞介素-6 受体作为预防冠心病的靶点：一项孟德尔随机分析。
Lancet. 2012 Mar 31;379(9822):1214-24. doi: 10.1016/S0140-6736(12)60110-X. Epub 2012 Mar 14.