Department of Medically Compromised Patients in Dentistry, School of Dentistry, University of Granada, Granada, Spain.
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9739-9743. doi: 10.26355/eurrev_202009_23065.
Remdesivir is a nucleotide analogue prodrug that inhibits viral RNA polymerases. It has been recognized recently as a promising antiviral drug against a wide array of RNA viruses (including SARS/MERS-CoV5). We aimed at determining which drugs used in dentistry interact with Remdesivir in order to avoid adverse reactions that may worsen the condition of patients with COVID-19.
A literature review was conducted to identify potential drug interactions between remdesivir (used in the treatment of COVID-19) and drugs prescribed in dentistry. The search was made in the databases PubMed and MEDLINE and official websites using key terms remdesivir, drug interactions and dentistry for articles published up to 31st July 2020.
According to the articles reviewed, a total of 279 drugs interact with Remdesivir. Two major interactions have been reported, 277 moderate drug interactions, and one with alcohol/food. The drug interactions involving drugs prescribed in dentistry are all moderate drug interactions and are (according to drug group): (1) antibiotics: azithromycin, clavulanate, doxycycline, erythromycin, levofloxacin; (2) antifungals: clotrimazole, fluconazole, itraconazole, ketoconazole; (3) non-steroidal anti-inflammatories (NAIDS): celecoxib diclofenac, etodolac, flurbiprofen, ibuprofen, ketoprofen, ketorolac, mefenamic acid, naproxen, piroxicam.
It is clinically necessary for oral health professionals to be aware of possible drug interactions that may occur between remdesivir and drugs commonly prescribed in dentistry in order to prevent adverse reactions that may even endanger the life of a patient with COVID-19.
瑞德西韦是一种核苷酸类似物前药，可抑制病毒 RNA 聚合酶。最近，人们发现它是一种针对多种 RNA 病毒（包括 SARS/MERS-CoV5）的有前途的抗病毒药物。我们旨在确定牙科中使用的哪些药物与瑞德西韦相互作用，以避免可能使 COVID-19 患者病情恶化的不良反应。
对瑞德西韦（用于治疗 COVID-19）与牙科处方药物之间潜在药物相互作用的文献进行了综述。使用关键词 remdesivir、drug interactions 和 dentistry 在 PubMed 和 MEDLINE 数据库以及官方网站上进行了搜索，检索截止日期为 2020 年 7 月 31 日。
根据综述的文章，共有 279 种药物与瑞德西韦相互作用。报告了两种主要相互作用，277 种中度药物相互作用，一种与酒精/食物相互作用。涉及牙科处方药物的药物相互作用均为中度药物相互作用，分别为：（1）抗生素：阿奇霉素、克拉维酸、多西环素、红霉素、左氧氟沙星；（2）抗真菌药：克霉唑、氟康唑、伊曲康唑、酮康唑；（3）非甾体抗炎药（NAIDS）：塞来昔布、双氯芬酸、依托度酸、氟比洛芬、布洛芬、酮洛芬、酮咯酸、甲芬那酸、萘普生、吡罗昔康。
口腔健康专业人员需要了解瑞德西韦与牙科常用药物之间可能发生的潜在药物相互作用，以防止可能危及 COVID-19 患者生命的不良反应，这在临床上是必要的。
