Biological and Health Psychology Department, Universidad Autónoma de Madrid, Madrid, Spain.
Brain Behav. 2020 Dec;10(12):e01872. doi: 10.1002/brb3.1872. Epub 2020 Oct 5.
To study the brain lateralization of the verbal emotional memory and the influence of the emotional valence, we investigated a sample composed of patients with medial temporal lobe refractory epilepsy (MTLE) treated with unilateral amygdalohippocampectomy compared to a control group.
MATERIALS & METHODS: A new task (Verbal Association) was designed and implemented to assess emotional memory performance. It was applied to 62 patients with MTLE of whom 31 have been subjected to right amygdalohippocampectomy and 31 to left amygdalohippocampectomy. These patients were compared with 31 participants with no cerebral pathology, as a control group.
(a) The control group obtained a higher number of recalled words than the rest of the groups, while the MTLE-right group obtained better results than the MTLE-left group. (b) In the case of positive emotional valence words, the MTLE-left group performed significantly worse than the rest of the groups; whereas for negative emotional words, the MTLE-left group presented the lowest average performance and the control group obtained a higher number of recalled words compared to MTLE-right group. In the case of neutral emotional words, no significant differences were found among the groups. (c) The MTLE-left group showed poorer performance on positive and negative words than neutral; the control group demonstrated lower average performance on positive and neutral words compared to negative; the MTLE-right group did not show any significant differences on the recall of different emotional valences.
Patients with MTLE show a deficit in the verbal recall which is exacerbated for information with an affective component. This deficit is more prominent in the case of patients with left unilateral resection (MTLE-left group) since they lose the benefits of the emotional information for the recall.
为了研究言语情绪记忆的大脑偏侧化以及情绪效价的影响，我们对一组接受单侧杏仁核海马切除术治疗的内侧颞叶耐药性癫痫（MTLE）患者进行了研究，并与对照组进行了比较。
设计并实施了一项新的任务（言语联想）来评估情绪记忆表现。该任务应用于 62 名 MTLE 患者，其中 31 名患者接受了右侧杏仁核海马切除术，31 名患者接受了左侧杏仁核海马切除术。这些患者与 31 名无脑部病理的参与者作为对照组进行了比较。
（a）对照组的回忆单词数高于其他组，而 MTLE-右组的成绩优于 MTLE-左组。（b）在正性情绪效价词方面，MTLE-左组的表现明显差于其他组；而在负性情绪词方面，MTLE-左组的平均表现最低，对照组的回忆单词数高于 MTLE-右组。在中性情绪词方面，各组之间没有发现显著差异。（c）MTLE-左组在回忆正性和负性词时表现较差，而在回忆中性词时则没有显著差异；对照组在回忆正性和中性词时的平均表现较低，而在回忆负性词时则没有显著差异；MTLE-右组在回忆不同情绪效价的词时没有表现出任何显著差异。
MTLE 患者在言语回忆方面存在缺陷，而对于带有情感成分的信息，这种缺陷会更加明显。这种缺陷在左侧单侧切除（MTLE-左组）的患者中更为突出，因为他们在回忆时失去了情感信息的益处。
