Singh Varsha, Grewal Kirat S, Vibha Deepti, Singh Rajesh K, Ramanujam Bhargavi, Nehra Ashima, Chandra Sarat P, Gaikwad Shailesh, Babu Indupriya, Tripathi Manjari
Psychology, Department of Humanities and Social Sciences, Indian Institute of Technology Delhi (IIT), New Delhi, 110016, India.
Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences, Delhi (AIIMS), Delhi, New Delhi 110029, India.
Brain Commun. 2023 Apr 24;5(2):fcad100. doi: 10.1093/braincomms/fcad100. eCollection 2023.
The Theory of Mind deficit due to cognitive-affective disintegration is a poorly understood cognitive consequence of cortical and subcortical disruption in right temporal lobe epilepsy. Following Marr's trilevel approach, we used the material-specific processing model to understand the Theory of Mind deficit in drug-resistant epilepsy ( = 30). We examined pre- and post-surgery changes in first-order (somatic-affective, non-verbal component) and second-order Theory of Mind (cognitive-verbal component) in three groups formed using: (i) seizure side (right versus left), (ii) right temporal epilepsy (right temporal lobe epilepsy versus non-right temporal lobe epilepsy), and (iii) right temporal lobe epilepsy with amygdalohippocampectomy (right temporal lobe epilepsy versus left temporal lobe epilepsy amygdalohippocampectomy versus non-amygdalohippocampectomy). We observed a marked deficit in the first-order Theory of Mind in the right temporal lobe amygdalohippocampectomy group; we mapped this deficit to decline in the non-verbal component of Theory of Mind (somatic-affective component). Preliminary results support using a material-specific processing model to understand the Theory of Mind deficits in right temporal lobe epilepsy amygdalohippocampectomy. Malleability of verbal processing in presence of deterioration of non-verbal processing might have clinical relevance for post-surgery recovery in right temporal lobe epilepsy amygdalohippocampectomy. Documenting the material-specific nature of deficits (verbal versus non-verbal) in non-western, linguistically, and socioeconomically diverse country enables us to understand the problem of heterogeneity in post-surgery cognitive consequences in the right amygdalohippocampectomy.
认知情感解体导致的心理理论缺陷是右颞叶癫痫中皮质和皮质下破坏所产生的一种尚未被充分理解的认知后果。遵循马尔的三层次方法，我们使用材料特异性加工模型来理解耐药性癫痫（n = 30）中的心理理论缺陷。我们在以下三组中检查了手术前后一阶（躯体情感、非语言成分）和二阶心理理论（认知语言成分）的变化：（i）癫痫发作侧（右侧与左侧），（ii）右颞叶癫痫（右颞叶癫痫与非右颞叶癫痫），以及（iii）接受杏仁核海马切除术的右颞叶癫痫（右颞叶癫痫与左颞叶癫痫杏仁核海马切除术与未行杏仁核海马切除术）。我们观察到右颞叶杏仁核海马切除术组一阶心理理论存在明显缺陷；我们将此缺陷归因于心理理论非语言成分（躯体情感成分）的下降。初步结果支持使用材料特异性加工模型来理解右颞叶癫痫杏仁核海马切除术中的心理理论缺陷。在非语言加工恶化的情况下语言加工的可塑性可能与右颞叶癫痫杏仁核海马切除术的术后恢复具有临床相关性。记录非西方、语言和社会经济背景多样的国家中缺陷（语言与非语言）的材料特异性性质，使我们能够理解右杏仁核海马切除术后认知后果的异质性问题。
