School of Materials Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou 450001, China.
ACS Appl Mater Interfaces. 2020 Oct 14;12(41):46827-46836. doi: 10.1021/acsami.0c15729. Epub 2020 Oct 5.
Hyaluronic acid (HA) is recognized as a functional carbohydrate polymer applied for the surface modification of cardiovascular implanted materials due to its molecular weight (MW) dependent cellular regulation. However, due to the enzyme digestion of hyaluronidase on HA in vivo, the stability of HA MW needs to be further improved. It has been reported that the stability of HA MW can be improved by sulfonation. In this study, sulfonated hyaluronic acids (S-HA) with sulfur content of 2.06, 3.69, 7.10, 8.98, and 9.71 were prepared through different sulfuric acid treatment procedures. Cell tests showed that S-HA with higher sulfur content played a significant role in promoting the proliferation and migration of endothelial cells and regulating smooth muscle cells to the physiological phenotype. In addition, it was also proved to inhibit the inflammatory macrophages adhesion/activation. Our data indicates that S-HA may be a better carbohydrate polymer for potential application of cardiovascular biomaterials.
透明质酸（HA）是一种功能性碳水化合物聚合物，因其分子量（MW）依赖性的细胞调节作用，而被应用于心血管植入材料的表面修饰。然而，由于体内透明质酸酶对 HA 的酶解作用，HA MW 的稳定性需要进一步提高。有报道称，HA MW 的稳定性可以通过磺化得到改善。在本研究中，通过不同的硫酸处理程序制备了硫酸化透明质酸（S-HA），其硫含量分别为 2.06、3.69、7.10、8.98 和 9.71。细胞试验表明，硫含量较高的 S-HA 对促进内皮细胞的增殖和迁移以及调节平滑肌细胞向生理表型转化具有显著作用。此外，还证明它可以抑制炎症巨噬细胞的黏附和激活。我们的数据表明，S-HA 可能是一种更好的碳水化合物聚合物，可用于心血管生物材料的潜在应用。
