is frequently silenced by CpG methylation and sensitizes lung cancer cells to paclitaxel and 5-FU.

To explore the biological functions and clinical significance of  in lung cancer. Methylation-specific PCR was used to measure promoter methylation of . The function of  was tested by Cell Counting Kit-8, colony formation, Transwell, flow cytometric analysis, acridine orange/ethidium bromide, chemosensitivity assay and xenograft assay.   is significantly downregulated by promoter methylation in lung cancer.  overexpression inhibits lung cancer cell migration and invasion. Furthermore, ectopic expression of  inhibits cell proliferation and by inducing G2/M cell cycle arrest, which sensitizes the chemosensitivity of lung cancer cells to paclitaxel and 5-fluorouracil, but not cisplatin.   is a tumor suppressor in non-small-cell lung cancer and can sensitize lung cancer cells to paclitaxel and 5-fluorouracil.