双功能催化下的催化对映选择性多米诺迈克尔/环间缩醛反应。
Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis.
机构信息
Department of Organic Chemistry II, University of the Basque Country, P. O. Box 644, 48080 Bilbao, Spain.
出版信息
Chem Commun (Camb). 2020 Nov 7;56(86):13149-13152. doi: 10.1039/d0cc05981a. Epub 2020 Oct 5.
PMID:33016279
Abstract
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes and in which three contiguous stereogenic centres, one of them a tertiary alcohol moiety, have been formed in a fully stereocontrolled fashion.
摘要
双功能叔胺/酰亚胺催化的对映选择性迈克尔加成反应已被用于引发迈克尔/跨环羟醛缩合级联反应，生成稠合取代的双环[5.4.0]十一烷，其中三个连续的手性中心，包括一个叔醇部分，以完全立体控制的方式形成。
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