Department of Neurology and Psychology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, P. R. China.
Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, P. R. China.
J Alzheimers Dis. 2020;78(2):673-681. doi: 10.3233/JAD-200156.
Late-life depression often coexists with vascular cognitive impairment and affects the quality of life for elders. However, little is known about cortical morphometric interactions between subcortical vascular mild cognitive impairment (svMCI) and concomitant mild depressive symptoms at the early stage.
We aimed to investigate cortical alterations of svMCI with and without depressive symptoms and determine whether these parameters are associated with depression symptoms and/or cognitive impairments.
Surface based morphometry was performed on 18 svMCI patients with depressive symptoms (svMCI + D), 16 svMCI patients without depressive symptoms (svMCI-D), and 23 normal controls (NC).
Compared to NC, both svMCI + D and svMCI-D patients exhibited significantly decreased surface area (SA) in many cortical areas. Interestingly, svMCI + D patients showed significantly increased rather than decreased SA in right lateral occipital gyrus (LOG.R), and a consistent trend of increased SA in these areas compared to svMCI-D. In addition, the svMCI + D showed increased gray matter volume of left pericalcarine (periCAL.L) than svMCI-D, whereas svMCI-D showed decreased gray matter volume of periCAL.L than NC. Further correlation analyses revealed that the SA of left superior temporal gyrus (STG.L) and right lateral orbital part of frontal gyrus (lorbFG.R) were significantly correlated with Hamilton depression rating scale of svMCI + D.
In conclusion, these results extend our insight into svMCI and add weight to reevaluation of concomitant early stage depressive symptoms. Moreover, we suggest that LOG.R∖periCAL.L∖STG.L∖lorbFG.R might serve as sensitive and trait-dependent biomarkers to detect concomitant depressive symptoms in svMCI patients.
老年期抑郁症常与血管性认知障碍共存，影响老年人的生活质量。然而，对于早期亚皮质血管性轻度认知障碍（svMCI）和伴随的轻度抑郁症状之间皮质形态计量学的相互关系知之甚少。
本研究旨在探讨伴有和不伴有抑郁症状的 svMCI 的皮质改变，并确定这些参数是否与抑郁症状和/或认知障碍相关。
对 18 例伴有抑郁症状的 svMCI 患者（svMCI+D）、16 例不伴有抑郁症状的 svMCI 患者（svMCI-D）和 23 名正常对照（NC）进行基于表面的形态计量学分析。
与 NC 相比，svMCI+D 和 svMCI-D 患者在许多皮质区域的表面积（SA）均显著降低。有趣的是，svMCI+D 患者右侧外侧枕叶（LOG.R）的 SA 显著增加，而不是降低，与 svMCI-D 相比，这些区域的 SA 呈一致的增加趋势。此外，svMCI+D 患者左侧距状旁回（periCAL.L）的灰质体积大于 svMCI-D，而 svMCI-D 患者的 periCAL.L 灰质体积小于 NC。进一步的相关分析显示，svMCI+D 的左侧颞上回（STG.L）和右侧额下回外侧眶部（lorbFG.R）的 SA 与 svMCI+D 的汉密尔顿抑郁评定量表显著相关。
总之，这些结果扩展了我们对 svMCI 的认识，并为重新评估伴有早期抑郁症状的 svMCI 提供了依据。此外，我们认为 LOG.R∖periCAL.L∖STG.L∖lorbFG.R 可能作为敏感且与特质相关的生物标志物，用于检测 svMCI 患者伴发的抑郁症状。
