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探讨调强放疗治疗局部晚期鼻咽癌肿瘤内空间异质性的 MRI 放射组学分析。

Exploring MRI based radiomics analysis of intratumoral spatial heterogeneity in locally advanced nasopharyngeal carcinoma treated with intensity modulated radiotherapy.

机构信息

A*STAR (Agency for Science, Technology and Research), Bioinformatics Institute, Singapore.

Divisions of Radiation Oncology, National Cancer Centre Singapore, Singapore.

出版信息

PLoS One. 2020 Oct 5;15(10):e0240043. doi: 10.1371/journal.pone.0240043. eCollection 2020.

DOI:10.1371/journal.pone.0240043
PMID:33017440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7535039/
Abstract

BACKGROUND

We hypothesized that spatial heterogeneity exists between recurrent and non-recurrent regions within a tumor. The aim of this study was to determine if there is a difference between radiomics features derived from recurrent versus non recurrent regions within the tumor based on pre-treatment MRI.

METHODS

A total of 14 T4NxM0 NPC patients with histologically proven "in field" recurrence in the post nasal space following curative intent IMRT were included in this study. Pretreatment MRI were co-registered with MRI at the time of recurrence for the delineation of gross tumor volume at diagnosis(GTV) and at recurrence(GTVr). A total of 7 histogram features and 40 texture features were computed from the recurrent(GTVr) and non-recurrent region(GTV-GTVr). Paired t-tests and Wilcoxon signed-rank tests were carried out on the 47 quantified radiomics features.

RESULTS

A total of 7 features were significantly different between recurrent and non-recurrent regions. Other than the variance from intensity-based histogram, the remaining six significant features were either from the gray-level size zone matrix (GLSZM) or the neighbourhood gray-tone difference matrix (NGTDM).

CONCLUSIONS

The radiomic features extracted from pre-treatment MRI can potentially reflect the difference between recurrent and non-recurrent regions within a tumor and has a potential role in pre-treatment identification of intra-tumoral radio-resistance for selective dose escalation.

摘要

背景

我们假设肿瘤内的复发和非复发区域之间存在空间异质性。本研究旨在确定基于治疗前 MRI，从肿瘤内复发和非复发区域提取的放射组学特征是否存在差异。

方法

本研究共纳入 14 例经组织学证实的接受根治性调强放疗（IMRT）后鼻后空间“场内”复发的 T4NxM0NPC 患者。治疗前 MRI 与复发时 MRI 进行配准，以勾画诊断时的大体肿瘤体积（GTV）和复发时的大体肿瘤体积（GTVr）。从复发（GTVr）和非复发区域（GTV-GTVr）计算了 7 个直方图特征和 40 个纹理特征。对 47 个定量放射组学特征进行了配对 t 检验和 Wilcoxon 符号秩检验。

结果

复发和非复发区域之间共有 7 个特征存在显著差异。除基于强度的直方图的方差外，其余 6 个显著特征均来自灰度大小区域矩阵（GLSZM）或邻域灰度差矩阵（NGTDM）。

结论

从治疗前 MRI 提取的放射组学特征可能反映肿瘤内复发和非复发区域之间的差异，并有可能在治疗前识别肿瘤内放射抵抗性，从而进行选择性剂量递增。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/83bd7aeeb280/pone.0240043.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/e6f24c160ac6/pone.0240043.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/441193a9154b/pone.0240043.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/d82737f4bc15/pone.0240043.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/9b40c94b1b0e/pone.0240043.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/83bd7aeeb280/pone.0240043.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/e6f24c160ac6/pone.0240043.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/441193a9154b/pone.0240043.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/d82737f4bc15/pone.0240043.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/9b40c94b1b0e/pone.0240043.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f043/7535039/83bd7aeeb280/pone.0240043.g005.jpg

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