Department of Chemistry & Chemical Biology, McMaster University, 1280 Main St. W., Hamilton, ON, L8S 4M1, Canada.
Chemistry. 2021 Mar 17;27(16):5057-5073. doi: 10.1002/chem.202003386. Epub 2021 Jan 18.
Highly efficient reactions that enable the assembly of molecules into complex structures have driven extensive progress in synthetic chemistry. In particular, reactions that occur under mild conditions and in benign solvents, while producing no by-products and rapidly reach completion are attracting significant attention. Amongst these, the strain-promoted azide-alkyne cycloaddition, involving various cyclooctyne derivatives reacting with azide-bearing molecules, has gained extensive popularity in organic synthesis and bioorthogonal chemistry. This reaction has also recently gained momentum in polymer chemistry, where it has been used to decorate, link, crosslink, and even prepare polymer chains. This survey highlights key achievements in the use of this reaction to produce a variety of polymeric constructs for disparate applications.
高效的反应能够将分子组装成复杂的结构，推动了合成化学的广泛发展。特别是在温和条件下、使用良性溶剂进行、不产生副产物且迅速完成的反应，正受到广泛关注。其中，应变促进的叠氮-炔环加成反应，涉及各种环辛炔衍生物与含叠氮分子的反应，在有机合成和生物正交化学中得到了广泛的应用。该反应最近在聚合物化学中也得到了发展，用于修饰、连接、交联，甚至制备聚合物链。本综述重点介绍了该反应在用于制备各种用于不同应用的聚合物结构方面的关键成就。
