Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Bioptical Laboratory Ltd, Pilsen, Czech Republic.
Diagn Cytopathol. 2021 Feb;49(2):241-251. doi: 10.1002/dc.24629. Epub 2020 Oct 5.
Fine-needle aspiration (FNA) is a key diagnostic method in the evaluation of salivary gland lesions. Secondary tumors of salivary glands represent only 5% of all malignancies of major salivary glands. The goal of our study was to examine the cytological and clinical features of secondary tumors sampled by FNA.
A series of 36 secondary tumors from the pathology departments of two university hospitals are presented. Clinical referrals to FNA, cytological features, immunohistochemical results, and histopathological diagnoses were reviewed in all cases.
The study population consisted of 36 cases (19 males and 17 females) with mean age 70.9 ± 13.0 years (range 41-96 years). The most common site of the metastasis was parotid gland (n = 26). The primary malignancy was known in 17 cases at the time of FNA diagnosis. The most common primary site was skin of head and neck area (11 cases) followed by lungs (n = 5) and tonsils (n = 5), kidney (n = 2) and breast (n = 2) and thyroid gland, gastrointestinal tract and soft tissue, 1 case of each. In 8 cases, the primary site remained unknown. The diagnostic or confirmatory immunocytochemistry was performed on cell blocks in 21 cases.
FNA is a reliable technique in the diagnosis of salivary gland secondary malignancies. The knowledge of the personal history of malignancy is essential for the successful immunocytochemical targeted diagnosis without any delay.
细针抽吸（FNA）是评估唾液腺病变的关键诊断方法。唾液腺的继发性肿瘤仅占大唾液腺所有恶性肿瘤的 5%。我们研究的目的是检查通过 FNA 取样的继发性肿瘤的细胞学和临床特征。
展示了来自两所大学医院病理科的 36 例继发性肿瘤系列。回顾了所有病例的临床转诊至 FNA、细胞学特征、免疫组织化学结果和组织病理学诊断。
研究人群由 36 例病例（19 名男性和 17 名女性）组成，平均年龄为 70.9±13.0 岁（范围为 41-96 岁）。转移的最常见部位是腮腺（n=26）。在 FNA 诊断时已知 17 例原发性恶性肿瘤。最常见的原发性部位是头颈部皮肤（11 例），其次是肺（n=5）和扁桃体（n=5）、肾脏（n=2）和乳房（n=2）以及甲状腺、胃肠道和软组织，各有 1 例。在 8 例中，原发性部位仍然未知。在 21 例病例中对细胞块进行了诊断或确认免疫细胞化学检查。
FNA 是诊断唾液腺继发性恶性肿瘤的可靠技术。了解恶性肿瘤的个人病史对于成功进行免疫细胞化学靶向诊断至关重要，不应有任何延误。
