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增强牙菌斑清除以改善牙龈健康:小苏打牙膏对牙菌斑和牙龈炎影响的3个月随机临床研究。

Enhanced plaque removal to improve gingival health: 3-month randomized clinical study of the effects of baking soda toothpaste on plaque and gingivitis.

作者信息

Sharma Naresh C, Goyal C R, Qaqish Jimmy G, Vorwerk Linda M, Hooper William J, Ghassemi Annahita

机构信息

BioSci Research Canada Ltd., Mississauga, Canada.

Sr. Clinical Research Scientist, Church and Dwight Co., Inc., Princeton, New Jersey, USA.

出版信息

Am J Dent. 2020 Oct;33(5):258-264.

Abstract

PURPOSE

To compare the effectiveness in reducing plaque and gingivitis of a fluoride toothpaste with 20% baking soda and a fluoride toothpaste control.

METHODS

159 subjects, who met the entry criteria, participated in this single-center, double-blind, randomized, parallel-group clinical study. Gingival Index (MGI), Gingival Bleeding Index (GBI), and Plaque Index (PI) were assessed after 4, 8, and 12 weeks use of the assigned test or control toothpaste. After 12 weeks, participants resumed 4 weeks of their customary oral hygiene after which they were re-evaluated using the same measures.

RESULTS

Both toothpastes statistically significantly reduced MGI, GBI, and PI versus baseline at all-time points. Brushing with the 20% baking soda toothpaste statistically significantly reduced MGI, PI, and GBI compared to the control toothpaste at all time points. After 12 weeks, the reductions in MGI, PI, and GBI were 12.6%, 9.6%, and 44.2%, respectively. After the 4-week customary oral hygiene period, the benefits of the study period had begun to diminish, but statistically significant reductions in MGI and GBI for the test versus control were still evident. This 3-month clinical study shows that brushing with fluoride toothpaste containing 20% baking soda reduces dental plaque and concurrently reduces gingival inflammation and bleeding compared to toothpaste with fluoride alone.

CLINICAL SIGNIFICANCE

Fluoride toothpaste with 20% baking soda has the potential to offer multiple oral health benefits when used as an adjunct to regular tooth brushing and, therefore, may be confidently recommended to patients.

摘要

目的

比较含20%小苏打牙膏与不含小苏打的对照氟化物牙膏在减少牙菌斑和牙龈炎方面的效果。

方法

159名符合入选标准的受试者参与了这项单中心、双盲、随机、平行组临床研究。在使用指定的测试牙膏或对照牙膏4周、8周和12周后,评估牙龈指数(MGI)、牙龈出血指数(GBI)和牙菌斑指数(PI)。12周后,参与者恢复4周的常规口腔卫生习惯,之后使用相同指标再次进行评估。

结果

与基线相比,两种牙膏在所有时间点均使MGI、GBI和PI出现统计学显著降低。与对照牙膏相比,使用含20%小苏打牙膏刷牙在所有时间点均使MGI、PI和GBI出现统计学显著降低。12周后,MGI、PI和GBI的降低幅度分别为12.6%、9.6%和44.2%。在4周的常规口腔卫生期后,研究期间的益处开始减弱,但与对照相比,测试牙膏在MGI和GBI方面仍有统计学显著降低。这项为期3个月的临床研究表明,与仅含氟化物的牙膏相比,使用含20%小苏打的氟化物牙膏刷牙可减少牙菌斑,同时减少牙龈炎症和出血。

临床意义

含20%小苏打的氟化物牙膏在作为常规刷牙的辅助手段使用时,有可能带来多种口腔健康益处,因此,可以放心地向患者推荐。

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