Lefkowitz M, Jorkasky D, Kornbluth J
Hum Immunol. 1987 Jun;19(2):139-49. doi: 10.1016/0198-8859(87)90101-7.
Natural killer (NK) activity was assessed in a prospective fashion in 15 renal transplant recipients receiving single HLA-haplotype matched allografts and maintained on cyclosporine (CYA) immunosuppression. There was marked variability in NK activity pretransplantation in this population; however, a strong correlation (r = 0.92, p less than 0.01) was found between determinations in an individual patient upon repeated testing. No significant depression of NK activity occurred within the first 12 weeks following transplantation. Whole blood CYA levels did not correlate with NK activity. Although NK activity prior to transplantation did not predict clinical outcome of the allograft, a marked rise in NK activity was observed in patients undergoing rejection compared with those not rejecting (p less than 0.01). A large increment in activity was seen in eight of 11 rejection episodes; a similar increase was rarely seen in the absence of rejection. These results indicate that NK activity is stimulated during allograft rejection in CYA treated renal transplant recipients. It remains to be determined whether this rise in NK function represents a manifestation of alloreactivity accompanying the rejection process or whether NK cells directly contribute to allograft destruction.
对15例接受单倍型人白细胞抗原（HLA）匹配同种异体移植并接受环孢素（CYA）免疫抑制治疗的肾移植受者进行了前瞻性自然杀伤（NK）活性评估。该人群移植前NK活性存在显著差异；然而，在对个体患者进行重复检测时，发现检测结果之间存在强相关性（r = 0.92，p < 0.01）。移植后的前12周内，NK活性没有出现显著降低。全血CYA水平与NK活性不相关。虽然移植前的NK活性不能预测同种异体移植的临床结果，但与未发生排斥反应的患者相比，发生排斥反应的患者NK活性显著升高（p < 0.01）。11次排斥反应中有8次出现活性大幅增加；在无排斥反应的情况下很少出现类似增加。这些结果表明，在接受CYA治疗的肾移植受者中，同种异体移植排斥反应期间NK活性受到刺激。NK功能的这种升高是代表伴随排斥反应过程的同种异体反应性表现，还是NK细胞直接导致同种异体移植破坏，仍有待确定。
