Renna Molajoni E, Barnaba V, Bachetoni A, Levrero M, Cinti P, Rossi M, Alfani D, Cortesini R
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:1042-6.
NK-1, NK-15 subsets and natural killer (NK) activity were studied in 13 patients, before undergoing renal transplantation and in the post-transplant period. Pretransplant there was a significant reduction of NK activity with a defect in Vmax capacity in all patients. NK-1+ and NK-15+ cell number was normal or slightly increased in all subjects. Post-transplant evaluation under cyclosporine immunosuppression showed a quantitative reduction in NK cells while no changes in NK activity and killing activity have been seen. We conclude that in spite of a numerical decrease, NK activity was not affected by cyclosporine treatment.
对13例患者在肾移植前及移植后阶段的NK-1、NK-15亚群和自然杀伤（NK）活性进行了研究。移植前，所有患者的NK活性显著降低，Vmax能力存在缺陷。所有受试者的NK-1+和NK-15+细胞数量正常或略有增加。在环孢素免疫抑制下进行的移植后评估显示NK细胞数量减少，而NK活性和杀伤活性未见变化。我们得出结论，尽管数量减少，但NK活性不受环孢素治疗的影响。
