Minosse Silvia, Garaci Francesco, Martino Federica, Mauro Roberta Di, Melis Milena, Giuliano Francesca Di, Picchi Eliseo, Floris Roberto, Guerrisi Maria, Girolamo Stefano Di, Toschi Nicola
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:1730-1733. doi: 10.1109/EMBC44109.2020.9175688.
Recent reports suggested that even moderate sudden sensorineural hearing loss (SSNHL) can be partly responsible for a loss of gray matter volume in the primary auditory cortex, hence reducing the capacity of the auditory cortical areas to react to sound stimulation. There is also evidence for a plastic reorganization of brain functional networks visible as enhanced local functional connectivity. The aim of this study was to use rs-fMRI, in conjunction with graph- theoretical analysis and a newly developed functional "disruption index" to study whole-brain as well as local functional changes in patients with acute and unilateral sensorineural hearing loss. No statistically significant differences in global or local network measures we found between SSNHL patients and healthy controls. However, when analyzing local metrics through the disruption index k, we found negative values for k which were statistically different from zero both in single subject analysis. Additionally, we found several associations between graph-theoretical metrics and clinical parameters.
最近的报告表明，即使是中度突发性感音神经性听力损失（SSNHL）也可能部分导致初级听觉皮层灰质体积减少，从而降低听觉皮层区域对声音刺激的反应能力。也有证据表明大脑功能网络存在可塑性重组，表现为局部功能连接增强。本研究的目的是使用静息态功能磁共振成像（rs-fMRI），结合图论分析和新开发的功能“破坏指数”，研究急性单侧感音神经性听力损失患者的全脑以及局部功能变化。我们发现SSNHL患者和健康对照之间在全局或局部网络测量上没有统计学显著差异。然而，当通过破坏指数k分析局部指标时，我们发现k值为负，在单受试者分析中，该值与零在统计学上有差异。此外，我们还发现了图论指标与临床参数之间的几种关联。
