Eichler Chad E, Cheng Leo K, Du Peng, Calder Stefan, Paskaranandavadivel Niranchan, Bradshaw Leonard A, Avci Recep
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2512-2515. doi: 10.1109/EMBC44109.2020.9175406.
The routine diagnosis of gastric motility disorders represents a significant problem to current clinical practice. Magnetogastrography (MGG) provides a non-invasive option for assessing gastric slow wave (SW) dysrhythmias that are associated with motility disorders. However, its ability to characterize SW propagation is impaired by the limited spatial coverage of existing superconducting quantum interference devices (SQUIDs). Recently developed optically-pumped magnetometers can potentially substitute SQUIDs and enable subject-specific MGG arrays with greater spatial coverage. This study developed simulations of gastric MGG to determine the distribution of the magnetic fields (MFs) generated by SWs above the torso, and investigated the impact of several realistic dysrhythmic patterns of propagation. The distribution of MFs was found to vary significantly for different patterns of SW propagation, with ectopic dysrhythmia displaying the greatest difference from normal. Notably, some important proportion of the MFs lay outside the coverage of an existing experimental SQUID array used in gastrointestinal research for some simulated SW propagation patterns, such as retrograde activity. Results suggest that MGG measurements should be made over the entire frontal face of the torso to capture all of the strongest MFs generated by SWs.Clinical relevance- This provides a guide for the placement of MGG sensors for the capture of both normal and dysrhythmic gastric slow wave propagation.
胃动力障碍的常规诊断是当前临床实践中的一个重大问题。胃磁图（MGG）为评估与动力障碍相关的胃慢波（SW）心律失常提供了一种非侵入性方法。然而，现有的超导量子干涉装置（SQUID）空间覆盖范围有限，影响了其对SW传播特征的描述能力。最近开发的光泵磁力仪有可能替代SQUID，并实现具有更大空间覆盖范围的针对个体的MGG阵列。本研究对胃MGG进行了模拟，以确定躯干上方SW产生的磁场（MF）分布，并研究了几种实际的节律异常传播模式的影响。发现不同SW传播模式下MF分布差异显著，异位节律异常与正常情况差异最大。值得注意的是，对于某些模拟的SW传播模式，如逆行活动，在用于胃肠研究的现有实验SQUID阵列覆盖范围之外存在相当一部分重要的MF。结果表明，应在躯干整个正面进行MGG测量，以捕捉SW产生的所有最强MF。临床意义——这为放置MGG传感器以捕捉正常和节律异常的胃慢波传播提供了指导。
