Grigoriadis Grigoris I, Sakellarios Antonis I, Kosmidou Ioanna, Naka Katerina K, Ellis Christopher, Michalis Lampros K, Fotiadis Dimitrios I
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2565-2568. doi: 10.1109/EMBC44109.2020.9175235.
In this study, we developed and analyzed different patient-specific 3D anatomical models of the left atrium including left atrial Appendage, in order to investigate the local hemodynamics. Particularly, we focused on the left atrial appendage and its impact on thrombus formation due to wall shear stress alterations. A 3D semi-automated reconstruction approach was carried out to segment and reconstruct the left atrium from CT scans. Six different patients were studied applying their patient-specific clinical data. Three different velocity profiles simulated for each patient case, representing one normal and two abnormal conditions. Simulations varied significantly according to different appendage morphologies. Our scope is to describe the hemodynamic behavior at the left atrium and the left atrial appendage according to different blood velocities based on their anatomic variety (chicken wing 0.14 m/s, windsock 0.10, cactus 0.08, and cauliflower 0.04). Wall shear stress results were demonstrated and correlated with the velocities and the thrombus formation inside the appendage cavity.
在本研究中，我们开发并分析了不同的包含左心耳的左心房患者特异性三维解剖模型，以研究局部血流动力学。特别地，我们聚焦于左心耳及其因壁面剪应力改变对血栓形成的影响。采用一种三维半自动重建方法从CT扫描中分割并重建左心房。应用六名不同患者的特定临床数据进行研究。针对每个患者病例模拟三种不同的速度剖面，分别代表一种正常情况和两种异常情况。模拟结果因不同的心耳形态而有显著差异。我们的目的是根据不同的血流速度及其解剖学差异（鸡翅形0.14米/秒、风袋形0.10米/秒、仙人掌形0.08米/秒和花椰菜形0.04米/秒）描述左心房和左心耳处的血流动力学行为。展示了壁面剪应力结果，并将其与心耳腔内的速度和血栓形成相关联。
