Wang Yaxin, Karnik Shweta, Smith P Alex, Elgalad Abdelmotagaly, Frazier O H, Kurita Nobuyuki
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2662-2666. doi: 10.1109/EMBC44109.2020.9175989.
Left ventricular assist devices (LVADs) have increasingly been used clinically to treat heart failure patients. However, hemolysis, pump thrombosis, infection and bleeding still persist as major limitations of LVAD technology. Assessing LVAD hemocompatibility using a blood shear stress device (BSSD) has clear advantages, as the BSSD could provide a better experimental platform to develop reliable, quantifiable blood trauma assays to perform iterative testing of LVAD designs. In this study, a BSSD was proposed with short blood exposure time and no seals or contact bearings to reduce blood trauma caused by the test platform. Enlarged air-gap drive motor in BSSD is essential to avoid high shear stress; however, it would significantly reduce the motor torque, which may result in inadequate force to drive the entire system. In order to evaluate and optimize the drive motor air-gap to ensure adequate motor torque as well as acceptable range for blood exposure time and shear stress, a numerical brushless DC (BLDC) motor model was established using finite element method (FEM) in numerical simulation software COMSOL. The model was first validated by the experimental results. Then numerical model with different air-gap was evaluated on the torque and speed constant changes. In the end, two equations were generated based on the curves derived from the torque and speed constant calculations. Determining these relationships between motor performance and motor air-gap will facilitate the development of an appropriate BLDC motor size for the BSSD, considering the design limitations in our future work.
左心室辅助装置(LVADs)在临床上越来越多地用于治疗心力衰竭患者。然而,溶血、泵血栓形成、感染和出血仍然是LVAD技术的主要局限性。使用血液剪切应力装置(BSSD)评估LVAD血液相容性具有明显优势,因为BSSD可以提供一个更好的实验平台,以开发可靠、可量化的血液损伤检测方法,对LVAD设计进行迭代测试。在本研究中,提出了一种BSSD,其血液暴露时间短,无密封件或接触轴承,以减少测试平台造成的血液损伤。BSSD中增大气隙驱动电机对于避免高剪切应力至关重要;然而,这会显著降低电机扭矩,可能导致驱动整个系统的力不足。为了评估和优化驱动电机气隙,以确保足够的电机扭矩以及可接受的血液暴露时间和剪切应力范围,在数值模拟软件COMSOL中使用有限元方法(FEM)建立了一个无刷直流(BLDC)电机数值模型。该模型首先通过实验结果进行验证。然后对具有不同气隙的数值模型进行扭矩和速度常数变化评估。最后,根据扭矩和速度常数计算得出的曲线生成了两个方程。考虑到我们未来工作中的设计限制,确定电机性能与电机气隙之间的这些关系将有助于为BSSD开发合适尺寸的BLDC电机。