Arathy R, Nabeel P M, Joseph Jayaraj, Abhidev V V, Sivaprakasam Mohanasankar
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2699-2702. doi: 10.1109/EMBC44109.2020.9175431.
We have developed an accelerometric system with a custom-designed patch probe and signal acquisition hardware to acquire the carotid wall displacement from the soft tissue surface for arterial stiffness evaluation. A subject-specific calibration model was developed to estimate the morphology of accurate carotid diameter waveform, using a standard ultrasound B-mode imaging system as the reference. Following the one-time calibration, the accelerometric system continuously acquired a non-invasive carotid lumen diameter waveform. The capability of the accelerometric system to measure the carotid stiffness index (β) in-vivo was experimentally validated by performing measurements on 8 normotensive subjects in the supine position. The repeatability and reproducibility of the results were investigated and were found to be comparable to those provided by ultrasound imaging systems. Further, the variation of arterial stiffness index measurements on different days was studied to verify the ability of the system to give a stable measure of stiffness. The accuracy of the observed results was confirmed with the state-of-art B-mode ultrasound imaging system. The results were found to be stable over a day, indicating the utility of the system for a reliable measure of non-invasive carotid arterial stiffness.
我们开发了一种带有定制设计的贴片探头和信号采集硬件的加速度测量系统，用于从软组织表面获取颈动脉壁位移，以评估动脉僵硬度。使用标准超声B模式成像系统作为参考，开发了一个特定受试者的校准模型，以估计准确的颈动脉直径波形形态。经过一次性校准后，加速度测量系统持续获取无创颈动脉管腔直径波形。通过对8名仰卧位的血压正常受试者进行测量，实验验证了加速度测量系统在体内测量颈动脉僵硬度指数（β）的能力。研究了结果的重复性和再现性，发现其与超声成像系统提供的结果相当。此外，研究了不同日期动脉僵硬度指数测量值的变化，以验证该系统给出稳定僵硬度测量值的能力。用最先进的B模式超声成像系统确认了观察结果的准确性。结果发现一天内是稳定的，表明该系统可用于可靠地测量无创颈动脉僵硬度。
