Ghadie Noor, St-Pierre Jean-Philippe, Labrosse Michel R
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2816-2819. doi: 10.1109/EMBC44109.2020.9176381.
In this computational modelling work, we explored the mechanical roles that various glycosaminoglycans (GAGs) distributions may play in the porcine ascending aortic wall, by studying both the transmural residual stress as well as the opening angle in aortic ring samples. A finite element (FE) model was first constructed and validated against published data generated from rodent aortic rings. The FE model was then used to simulate the response of porcine ascending aortic rings with different GAG distributions prescribed through the wall of the aorta. The results indicated that a uniform GAG distribution within the aortic wall did not induce residual stresses, allowing the aortic ring to remain closed when subjected to a radial cut. By contrast, a heterogeneous GAG distribution led to the development of residual stresses which could be released by a radial cut, causing the ring to open. The residual stresses and opening angle were shown to be modulated by the GAG content, gradient, and the nature of the transmural distribution.
在这项计算建模工作中，我们通过研究跨壁残余应力以及主动脉环样本中的开口角度，探讨了各种糖胺聚糖（GAGs）分布在猪升主动脉壁中可能发挥的力学作用。首先构建了一个有限元（FE）模型，并根据从啮齿动物主动脉环生成的已发表数据进行了验证。然后使用该FE模型来模拟猪升主动脉环在不同GAG分布情况下的响应，这些分布是通过主动脉壁规定的。结果表明，主动脉壁内均匀的GAG分布不会诱导残余应力，当进行径向切割时，主动脉环能够保持闭合。相比之下，不均匀的GAG分布会导致残余应力的产生，这些残余应力可通过径向切割释放，从而使环打开。结果显示，残余应力和开口角度受GAG含量、梯度以及跨壁分布性质的调节。
