Effects of Fractal Electrode Geometry in Charge Injection Capacity of TiN Microelectrodes.

Microelectrodes are basic tools for investigating small-scale brain dynamics. Noble metals such as gold (Au), platinum (Pt), and iridium oxide (IrO) have been used as an electrode material because of their biocompatibility and good charge transfer capability. Their main charge transfer mechanism is the Faradaic process with redox reactions. Unfortunately, the decrease in electrode size accelerates the irreversible electrochemical dissolution during electrical stimulation due to increased current density. The dissolution can be prevented by alternating the electrode material to capacitive charge injection materials such as titanium nitride (TiN). However, electrical conductivity of TiN is relatively lower than the noble metals, which results in a lower charge injection capability. Therefore, there is a need to increase the charge injection limit of TiN electrodes for a high-performing neurostimulation. Our previous work suggested that the Vicseck fractal design can increase the charge injection limit of the microelectrodes. In this work, the effects of the fractal design in capacitive charge injection material were experimentally investigated by using TiN microelectrodes with circular and fractal designs. We measured the cyclic voltammetry, electrochemical impedance spectroscopy, and voltage transients. In addition, the charge injection limits of theses microelectrodes were estimated to quantify the effects of planar geometry on TiN microelectrodes. Despite our previous results showing superior charge injection capability of fractal Pt microelectrodes, the TiN showed no significant improvements due to the fractal geometry. This may be because the increase in charge injection capability of fractal microelectrodes is due to increased Faradaic charge injection process, which is minimized for TiN materials. Thus, our data suggests that the material as well as the geometry of the microelectrodes play key roles in optimizing stimulation microelectrode performance.Clinical relevance-As with the Faradaic charge injection-dominant materials, the capacitive charge injection materials could also benefit from additional investigation to fully characterize effects of electrode geometry for improved neurostimulation performance.