Krempp Constantin, Paulk Angelique C, Truccolo Wilson, Cash Sydney S, Zelmann Rina
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:3586-3589. doi: 10.1109/EMBC44109.2020.9175404.
Sleep spindles are transient oscillations in the brain related to sleep consolidation and memory. We investigated if brief, localized electrical pulses could perturb spindles on five human patients with intracerebral electrodes implanted for clinical purpose. We used a closed-loop setup to specifically detect spindles and stimulate in real-time during these events. Stimulation latency was 200-400 ms following spindle onset. Analyzing the intracranial electro-encephalographic (iEEG) data both locally and globally, we found, in two of the patients, that single pulse stimulation could stop the spindles locally. Spindles were shorter than those without stimulation and a decrease in power at the same frequency as spindles was observed following stimulation.Clinical Relevance- This study shows that brief and precise electrical stimulation may be used to modulate oscillatory behavior of the human brain. Applied to sleep spindles, further studies may establish that single pulses applied in a closed-loop manner could be used to modulate memory and could help understand effect of neuromodulation in sleep disruption.
睡眠纺锤波是大脑中与睡眠巩固和记忆相关的短暂振荡。我们研究了短暂的局部电脉冲是否会干扰五名因临床目的植入脑内电极的人类患者的纺锤波。我们使用闭环装置在这些事件期间专门检测纺锤波并进行实时刺激。刺激潜伏期为纺锤波开始后200 - 400毫秒。通过对颅内脑电图（iEEG）数据进行局部和整体分析，我们发现，在两名患者中，单脉冲刺激可以局部停止纺锤波。纺锤波比未受刺激时更短，并且在刺激后观察到与纺锤波相同频率的功率下降。临床意义——本研究表明，短暂而精确的电刺激可用于调节人类大脑的振荡行为。应用于睡眠纺锤波，进一步的研究可能会证实，以闭环方式施加的单脉冲可用于调节记忆，并有助于理解神经调节在睡眠中断中的作用。
