Rudin Vanessa, Lubow Eric, Bundy Nicole, Lytle Millennia, Culjat Martin, Dyhrberg Mette
Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:5402-5405. doi: 10.1109/EMBC44109.2020.9175209.
Systemic lupus erythematosus (SLE) is a complex, multi-system autoimmune disease of unclear etiology that causes significant morbidity and, in severely affected patients, early mortality. Despite efforts from academic and private research entities, pharmaceutical companies, and patient advocacy groups, and hundreds of millions of dollars in spending, numerous gaps in care still exist. A digital therapeutic platform is described that uses self-tracking technology, analytics, and telehealth coaching to identify and remove possible dietary and/or other lifestyle triggers of SLE. A clinical proof of concept study was performed with 18 SLE patients over a 12 week program. All participants reported improvements in their symptoms, including pain, fatigue, digestive, and other physical symptoms.Clinical Relevance- This study demonstrates the technical and clinical feasibility of a digital therapeutic platform to improve the health-related quality of life in patients with systemic lupus erythematosus.
系统性红斑狼疮（SLE）是一种病因不明的复杂多系统自身免疫性疾病，可导致严重发病，在重症患者中还会导致早期死亡。尽管学术和私人研究机构、制药公司以及患者权益倡导组织付出了努力，花费了数亿美元，但护理方面仍存在许多差距。本文介绍了一种数字治疗平台，该平台利用自我追踪技术、分析方法和远程医疗指导来识别并消除系统性红斑狼疮可能的饮食和/或其他生活方式诱因。在一项为期12周的项目中，对18名系统性红斑狼疮患者进行了临床概念验证研究。所有参与者均报告其症状有所改善，包括疼痛、疲劳、消化问题和其他身体症状。临床意义——本研究证明了数字治疗平台改善系统性红斑狼疮患者健康相关生活质量的技术和临床可行性。
