Covariance intersection to improve the robustness of the photoplethysmogram derived respiratory rate.

Respiratory rate (RR) can be estimated from the photoplethysmogram (PPG) recorded by optical sensors in wearable devices. The fusion of estimates from different PPG features has lead to an increase in accuracy, but also reduced the numbers of available final estimates due to discarding of unreliable data. We propose a novel, tunable fusion algorithm using covariance intersection to estimate the RR from PPG (CIF). The algorithm is adaptive to the number of available feature estimates and takes each estimates' trustworthiness into account. In a benchmarking experiment using the CapnoBase dataset with reference RR from capnography, we compared the CIF against the state-of-the-art Smart Fusion (SF) algorithm. The median root mean square error was 1.4 breaths/min for the CIF and 1.8 breaths/min for the SF. The CIF significantly increased the retention rate distribution of all recordings from 0.46 to 0.90 (p < 0.001). The agreement with the reference RR was high with a Pearson's correlation coefficient of 0.94, a bias of 0.3 breaths/min, and limits of agreement of -4.6 and 5.2 breaths/min. In addition, the algorithm was computationally efficient. Therefore, CIF could contribute to a more robust RR estimation from wearable PPG recordings.