Chen Qi, Zhou Jun, Zhang Xinxia, Wang Lizhen, Yang Botong, Xia Jia, Zhong Min, Tang Xiaoming
Hospital of Chengdu University of Traditional Chinese Medicine.
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Medicine (Baltimore). 2020 Oct 2;99(40):e22276. doi: 10.1097/MD.0000000000022276.
Thyroid nodules are scattered lesions caused by abnormal local growth of thyroid cells. In recent years, their prevalence rate has been rising gradually, and the probability of cancerations has also been increasing gradually. Therefore, we must pay more attention to them and carry out early intervention. However, at present, most of the intervention measures for patients with thyroid nodules are mainly clinical observation and follow-up, and no clear and effective drug intervention therapy has been proposed. The curative effect of acupuncture on thyroid nodules has been proved clinically. However, as there is no clear mechanism of action, no specific operation methods or Suggestions, it is necessary to make a systematic evaluation of acupuncture therapy, so as to lay a foundation for further research in the future.
The following databases will be searched from their inception to June 2020: Electronic database includes PubMed, Embase, Cochrane Library, Web of Science, Nature, Science online, Chinese Biomedical Database WanFang, VIP medicine information, and China National Knowledge Infrastructure (CNKI). Primary outcomes: Color ultrasound of thyroid and cervical lymph nodes, FT3, FT4, TSH, TGAB, TPOAB, insulin resistance index (HOMA-IR). Data will be extracted by 2 researchers independently, risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0.
The results of this study will systematically evaluate the efficacy and safety of acupuncture therapy for patients with thyroid nodule.
Through the systematic review of this study, the evidence of the treatment of thyroid nodule by acupuncture has been summarized so far, so as to provide guidance for further promoting the application of acupuncture therapy in patients with thyroid nodule.
This study is a systematic review, the outcomes are based on the published evidence, so examination and agreement by the ethics committee are not required in this study. We intend to publish the study results in a journal or conference presentations.
OPEN SCIENCE FRA NETWORK (OSF) REGISTRATION NUMBER: August 18, 2020. osf.io/uzck4. (https://osf.io/uzck4).
甲状腺结节是甲状腺细胞局部异常生长引起的散在病变。近年来，其患病率逐渐上升，癌变概率也在逐渐增加。因此，我们必须更加重视并进行早期干预。然而，目前甲状腺结节患者的干预措施大多主要是临床观察和随访，尚未提出明确有效的药物干预治疗方法。针刺治疗甲状腺结节的疗效已得到临床证实。但由于作用机制不明确，缺乏具体的操作方法或建议，有必要对针刺疗法进行系统评价，为今后进一步研究奠定基础。
检索自建库至2020年6月的以下数据库：电子数据库包括PubMed、Embase、Cochrane图书馆、Web of Science、Nature、Science online、中国生物医学数据库万方、维普医药信息和中国知网（CNKI）。主要结局指标：甲状腺及颈部淋巴结彩色超声、FT3、FT4、TSH、TGAB、TPOAB、胰岛素抵抗指数（HOMA-IR）。由2名研究人员独立提取数据，基于Cochrane系统评价干预措施手册评估Meta分析的偏倚风险。所有数据分析将采用数据统计软件Review Manager V.5.3和Stata V.12.0进行。
本研究结果将系统评价针刺疗法治疗甲状腺结节患者的疗效和安全性。
通过本研究的系统评价，总结了目前针刺治疗甲状腺结节的证据，为进一步推广针刺疗法在甲状腺结节患者中的应用提供指导。
本研究为系统评价，结局基于已发表的证据，因此本研究无需伦理委员会审查和批准。我们计划在期刊上发表研究结果或在会议上进行汇报。
开放科学框架（OSF）注册号：2020年8月18日。osf.io/uzck4。（https://osf.io/uzck4）
