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食管癌切除术后迟发性吻合口漏:一例报告并文献复习

Late-onset anastomotic leak following sweet esophagectomy: A case report and review of the literature.

作者信息

Kong Feng-Wei, Wang Wei-Min, Liu Lei, Wu Wen-Bin, Gong Long-Bo, Zhang Miao

机构信息

Department of General Surgery, Xuzhou Infectious Disease Hospital, Xuzhou.

Department of Gastroenterology of Yichang Central People's Hospital, Institute of Digestive Disease, China Three Gorges University, Yichang.

出版信息

Medicine (Baltimore). 2020 Oct 2;99(40):e22479. doi: 10.1097/MD.0000000000022479.

DOI:10.1097/MD.0000000000022479
PMID:33019440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7535676/
Abstract

RATIONALE

Late-onset anastomotic leak (AL) is an uncommon but potentially lethal complication after esophagectomy.

PATIENT CONCERNS

A 74-year-old male patient was readmitted due to chest distress and chills about 3 months after initial esophagectomy for cancer.

DIAGNOSES

The previous endoscopic biopsy revealed primary esophageal squamous cell carcinoma, and sweet esophagectomy with gastric conduit reconstruction was therefore performed. The patient developed AL 3 months after the surgery.

INTERVENTIONS

Naso-leakage extraluminal drainage tube was utilized because the symptoms of the patient were aggravated 1 month after the chest tube drainage since his second admission for AL.

OUTCOMES

Twenty-one days after naso-leakage extraluminal drainage, the computed tomography images showed the healing of the leakage. Then the patient was discharged from the hospital.

LESSONS

Late-onset AL should be kept in mind when the patient complained of chest distress and fever during the follow up after esophagectomy. In addition, naso-leakage extraluminal drainage could be considered for the treatment of AL. Further trials for better evidence are warranted.

摘要

理论依据

迟发性吻合口漏(AL)是食管切除术后一种罕见但可能致命的并发症。

患者情况

一名74岁男性患者在初次因癌症行食管切除术后约3个月,因胸部不适和寒战再次入院。

诊断

先前的内镜活检显示为原发性食管鳞状细胞癌,因此进行了食管切除加胃代食管重建术。患者术后3个月发生了AL。

干预措施

因患者第二次因AL入院后,胸腔闭式引流1个月后症状加重,故采用鼻漏腔外引流管。

结果

鼻漏腔外引流21天后,计算机断层扫描图像显示漏口愈合。随后患者出院。

经验教训

食管切除术后随访期间,当患者出现胸部不适和发热时,应考虑迟发性AL。此外,对于AL的治疗可考虑采用鼻漏腔外引流。有必要进行进一步试验以获得更好的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0142/7535676/b2866e665c02/medi-99-e22479-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0142/7535676/d2da86c952a0/medi-99-e22479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0142/7535676/b2866e665c02/medi-99-e22479-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0142/7535676/d2da86c952a0/medi-99-e22479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0142/7535676/b2866e665c02/medi-99-e22479-g002.jpg

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本文引用的文献

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International multicenter expert survey on endoscopic treatment of upper gastrointestinal anastomotic leaks.关于上消化道吻合口漏内镜治疗的国际多中心专家调查
Endosc Int Open. 2019 Dec;7(12):E1671-E1682. doi: 10.1055/a-1005-6632. Epub 2019 Nov 25.
2
Systematic Review of the Role of Biomarkers in Predicting Anastomotic Leakage Following Gastroesophageal Cancer Surgery.生物标志物在预测食管癌手术后吻合口漏中的作用的系统评价
J Clin Med. 2019 Nov 17;8(11):2005. doi: 10.3390/jcm8112005.
3
Successful treatment of large cavity esophageal disruptions with transluminal washout and endoscopic vacuum therapy: a report of two cases.
经腔冲洗和内镜下真空治疗成功治疗巨大食管破裂:两例报告
Ther Adv Gastrointest Endosc. 2019 Jul 10;12:2631774519860300. doi: 10.1177/2631774519860300. eCollection 2019 Jan-Dec.
4
Early detection of complications: anastomotic leakage.并发症的早期检测:吻合口漏
J Thorac Dis. 2019 Apr;11(Suppl 5):S805-S811. doi: 10.21037/jtd.2018.11.55.
5
Management of intrathoracic and cervical anastomotic leakage after esophagectomy for esophageal cancer: a systematic review.食管癌术后胸内和颈部吻合口瘘的处理:系统评价。
World J Emerg Surg. 2019 Apr 4;14:17. doi: 10.1186/s13017-019-0235-4. eCollection 2019.
6
Utility of routine oral contrast study for detecting postesophagectomy anastomotic leak - a systematic review and meta-analysis.常规口服对比研究在检测食管切除术后吻合口漏中的应用 - 系统评价和荟萃分析。
Dis Esophagus. 2019 Jul 1;32(7). doi: 10.1093/dote/doz011.
7
Endoscopic Full-Thickness Defects and Closure Techniques.内镜全层缺损及闭合技术
Curr Treat Options Gastroenterol. 2018 Dec;16(4):386-405. doi: 10.1007/s11938-018-0199-6.
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Meta-analysis of the impact of postoperative complications on survival after oesophagectomy for cancer.癌症食管癌切除术后并发症对生存影响的Meta分析
BJS Open. 2018 Apr 19;2(5):276-284. doi: 10.1002/bjs5.64. eCollection 2018 Sep.
9
Practice of cervical end-esophageal exteriorization in patients with severe intrathoracic anastomotic leakage after esophagectomy.食管癌切除术后严重胸段吻合口漏患者的颈段食管外置术实践
J Int Med Res. 2018 Dec;46(12):5090-5098. doi: 10.1177/0300060518790405. Epub 2018 Aug 8.
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Dis Esophagus. 2018 Nov 1;31(11). doi: 10.1093/dote/doy060.