针刺治疗三叉神经痛的疗效与安全性：一项系统评价与Meta分析方案
Efficacy and safety of acupuncture for trigeminal neuralgia: A protocol for systematic review and meta-analysis.
作者信息
Zhao Qinyu, He Guang, Zhang Zhenyan, Li Zhanbiao
机构信息
College of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Shandong.
Acupuncture Department.
出版信息
Medicine (Baltimore). 2020 Oct 2;99(40):e22589. doi: 10.1097/MD.0000000000022589.
BACKGROUND
Trigeminal neuralgia (TN) is a disease accompanied by severe facial pain, which seriously affects the daily life of patients. Acupuncture is widely used by Traditional Chinese Medicine doctors to treat various painful diseases. Acupuncture combined with the treatment of trigeminal neuralgia can increase the analgesic effect and reduce side effects. However, there is still a lack of more quality multi-center clinical controlled trials and comprehensive meta-analysis, and a lack of more comprehensive and stronger evidence-based medical evidence.
METHODS
The 2 reviewers used the same search strategy to search CNKI, PubMed, Web of Science, Cochrane Library, Scopus, EBSCO, and the search date is until July 19, 2020. Two people read the retrieved literatures independently, and then delete duplications. Then, use the "risk of bias" tool in Cochrane Handbook 5.2 to score. Only documents with a score greater than 5 can be included. Make a table of literature characteristics, extract baseline patient data, research methods and possible risks of bias in the literature, interventions in treatment and control groups, outcome evaluation indicators (BNI, VAS, ER and AE), and research funding support. Use Review Manager 5.3.5 for meta-analysis, use Stata 15 for regression analysis to find the source of heterogeneity, and then perform subgroup analysis to resolve the heterogeneity based on the corresponding source.
RESULTS
The analysis of BNI, VAS, ER and AE data can provide high-quality evidence for high-quality synthesis and/or descriptive analysis of the effectiveness and safety of acupuncture treatment of various causes of urinary retention.
CONCLUSION
This study can provide more comprehensive and strong evidence to prove whether acupuncture is effective and safe in the treatment of TN patients.
REGISTRATION
The research has been registered and approved on the PROSPERO website. The registration number is CRD42019119606.
背景
三叉神经痛（TN）是一种伴有严重面部疼痛的疾病，严重影响患者的日常生活。针灸被中医医生广泛用于治疗各种疼痛性疾病。针灸联合治疗三叉神经痛可提高镇痛效果并减少副作用。然而，目前仍缺乏更多高质量的多中心临床对照试验和综合荟萃分析，缺乏更全面、更有力的循证医学证据。
方法
两名审阅者采用相同的检索策略检索中国知网、PubMed、科学网、考克兰图书馆、Scopus、EBSCO，检索日期截至2020年7月19日。两人独立阅读检索到的文献，然后删除重复文献。然后，使用考克兰手册5.2中的“偏倚风险”工具进行评分。仅纳入得分大于5的文献。制作文献特征表，提取文献中患者的基线数据、研究方法和可能的偏倚风险、治疗组和对照组的干预措施、结局评估指标（BNI、VAS、ER和AE）以及研究资金支持情况。使用Review Manager 5.3.5进行荟萃分析，使用Stata 15进行回归分析以找出异质性来源，然后基于相应来源进行亚组分析以解决异质性。
结果
对BNI、VAS、ER和AE数据的分析可为针灸治疗各种原因引起的尿潴留的有效性和安全性的高质量综合和/或描述性分析提供高质量证据。
结论
本研究可为证明针灸治疗TN患者是否有效及安全提供更全面、有力的证据。
注册情况
本研究已在PROSPERO网站注册并获得批准。注册号为CRD42019119606。
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