West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra LG 54, Ghana.
Department of Biochemistry, Kogi State University, Anyigba P.M.B 1007, Nigeria.
Exp Biol Med (Maywood). 2021 Jan;246(1):10-19. doi: 10.1177/1535370220961764. Epub 2020 Oct 5.
malaria is a global health problem. Erythrocyte invasion by merozoites appears to be a promising target to curb malaria. We have identified and characterized a novel protein that is involved in erythrocyte invasion. Our data on protein subcellular localization, stage-specific protein expression pattern, and merozoite invasion inhibition by α-peptide antibodies suggest a role for PF3D7_1459400 protein during erythrocyte invasion. Even more, the human immunoepidemiology data present PF3D7_1459400 protein as an immunogenic antigen which could be further exploited for the development of new anti-infective therapy against malaria.
疟疾是一个全球性的健康问题。疟原虫入侵红细胞似乎是抑制疟疾的一个有前途的靶点。我们已经鉴定和描述了一种参与红细胞入侵的新蛋白。我们关于蛋白亚细胞定位、阶段特异性蛋白表达模式以及α肽抗体对裂殖子入侵的抑制的数据表明，PF3D7_1459400 蛋白在红细胞入侵过程中发挥作用。更重要的是，人类免疫流行病学数据表明 PF3D7_1459400 蛋白是一种免疫原性抗原，可以进一步开发用于治疗疟疾的新抗感染疗法。
