International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa.
Division of Immunology, Institute of Infectious Disease and Molecular Medicine (IDM), Health Science Faculty, University of Cape Town, Wernher and Beit Building, South, Cape Town, 7925, South Africa.
Sci Rep. 2020 Oct 5;10(1):16506. doi: 10.1038/s41598-020-73574-3.
Like pro-inflammatory cytokines, the role of anti-inflammatory cytokines in both learning and memory has been investigated, revealing beneficial effects for both interleukin-4 and interleukin-13 via the common interleukin-4 receptor alpha chain complex. In this study, using the Morris water maze spatial task for cognition, we compared interleukin-4 receptor alpha- deficient mice and their ligands interleukin-4/ interleukin-13 double deficient mice, on a Balb/c background. We demonstrate that while interleukin-4/ interleukin-13 double deficient mice are significantly impaired in both learning and reference memory, interleukin-4 receptor alpha-deficiency impairs only reference memory, compared to the wild-type control mice. In order to better understand how interleukin-4 receptor alpha- deficient mice are able to learn but not remember, we investigated the BDNF/TrkB- and the ARC-signaling pathways. We show that interleukin-4 receptor alpha-deficiency disrupts activation of BDNF/TrkB- and ARC-signaling pathways during reference memory, while the pathway for spatial learning is spared.
类似于促炎细胞因子，抗炎细胞因子在学习和记忆中的作用也已经得到了研究，结果表明白细胞介素-4 和白细胞介素-13 通过共同的白细胞介素-4 受体α 链复合物发挥有益作用。在这项研究中，我们使用 Morris 水迷宫空间任务来评估认知功能，比较了 Balb/c 背景下缺乏白细胞介素-4 受体α 的小鼠及其配体白细胞介素-4/白细胞介素-13 双重缺陷型小鼠。结果表明，尽管白细胞介素-4/白细胞介素-13 双重缺陷型小鼠在学习和参考记忆方面都受到显著损害，但与野生型对照小鼠相比，白细胞介素-4 受体α 缺陷型小鼠仅损害参考记忆。为了更好地理解白细胞介素-4 受体α 缺陷型小鼠能够学习但不能记忆的原因，我们研究了 BDNF/TrkB-和 ARC 信号通路。结果表明，白细胞介素-4 受体α 缺陷型小鼠在参考记忆期间破坏了 BDNF/TrkB-和 ARC 信号通路的激活，而空间学习的通路则未受影响。
