Ogata M, Matsumoto H, Shimizu S, Kida S, Shiro M, Tawara K
J Med Chem. 1987 Aug;30(8):1348-54. doi: 10.1021/jm00391a014.
Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.
