Institute for Medical Microbiology and Hospital Hygiene, Philipps University Marburg, 35043 Marburg, Germany.
Institute of Pathology, University Hospital Giessen-Marburg, 35043 Marburg, Germany.
Int J Mol Sci. 2020 Oct 3;21(19):7307. doi: 10.3390/ijms21197307.
The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor-stroma interactions. PDAC has proven particularly refractory to novel immunotherapies, which is a fact that is mediated by a unique assemblage of various immune cells creating a strongly immunosuppressive environment in which this cancer type thrives. In this review, we outline currently available knowledge on the cross-talk between tumor cells and the cellular immune microenvironment, highlighting the physiological and pathological cellular interactions, as well as the resulting therapeutic approaches derived thereof. Hopefully a better understanding of the complex tumor-stroma interactions will one day lead to a significant advancement in patient care.
实体肿瘤的生物学特性主要由癌细胞与其周围微环境的相互作用决定。在这方面，胰腺癌（胰腺导管腺癌，PDAC）是多种可能的肿瘤-基质相互作用的典型范例。PDAC 对新型免疫疗法特别具有抗性，这一事实是由各种免疫细胞的独特组合介导的，这些免疫细胞形成了强烈的免疫抑制环境，使这种癌症类型得以生长。在这篇综述中，我们概述了目前关于肿瘤细胞与细胞免疫微环境之间相互作用的知识，强调了生理和病理细胞相互作用，以及由此产生的治疗方法。希望对复杂的肿瘤-基质相互作用有更深入的了解，有朝一日能为患者护理带来重大进展。
