Krupski Witold, Kruk-Bachonko Joanna, Tatara Marcin R
II Department of Radiology, Medical University in Lublin, ul. Staszica 16, 20-081 Lublin, Poland.
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Akademicka 12, 20-950 Lublin, Poland.
Medicina (Kaunas). 2020 Oct 2;56(10):518. doi: 10.3390/medicina56100518.
During osteopetrosis course, impaired bone remodeling induces skeletal osteosclerosis and abnormally dense bones, which, however, are brittle and susceptible to low-energy fractures. In this study, radiological evaluation and densitometric measurements of several bones of the skeleton in one of the oldest patients in the world suffering from osteopetrosis was presented. : Volumetric bone mineral density measurements of the examined bones in an 80-year-old man were performed using two different quantitative computed tomography techniques. The obtained results show higher values of the volumetric bone mineral density of the trabecular bone in lumbar spine than in the cortical bone compartment. T-score and Z-score in this patient reached values of 27-28 and 31-32, respectively. The obtained densitometric data may serve for further diagnostic purposes of osteopetrosis. As documented, the severity of the osteosclerotic changes of bones were higher in this patient than in most other described cases. Moreover, radiological signs diagnosed in this patient were characteristic for all types of osteopetrosis making this case very uncommon.
在骨硬化症病程中,受损的骨重塑会导致骨骼骨硬化和骨密度异常增高,然而,这些骨骼很脆,易发生低能量骨折。在本研究中,对世界上最年长的骨硬化症患者之一的多块骨骼进行了放射学评估和骨密度测量。使用两种不同的定量计算机断层扫描技术对一名80岁男性受检骨骼进行了骨体积密度测量。所得结果显示,腰椎小梁骨的骨体积密度值高于皮质骨部分。该患者的T值和Z值分别达到27 - 28和31 - 32。所获得的骨密度数据可用于骨硬化症的进一步诊断。据记载,该患者骨骼骨硬化改变的严重程度高于大多数其他已描述病例。此外,该患者诊断出的放射学征象是所有类型骨硬化症的特征,使得该病例非常罕见。