Akiba T, Saijo N, Miyamoto K, Taguchi J, Taito H, Sakurai M, Tamura T, Sasaki Y, Eguchi K, Shinkai T
Jpn J Clin Oncol. 1987 Jun;17(2):173-8.
A 56-year-old housewife was incidentally discovered to have an abnormal shadow in the right B6 area upon a chest X-ray film being taken. A transcutaneous lung biopsy of the mass revealed adenocarcinoma of the lung (WHO classification). A brain computed tomography (CT) scan demonstrated multiple brain metastasis. Following whole brain irradiation, carboplatin (CBDCA) (450 mg/m2) was administered by intravenous drip infusion on March 7, 1986. After three weeks of initial treatment with CBDCA, the size of the tumor in the primary site was found to have decreased on the chest X-ray film by more than 50%, following which, similar doses of CBDCA were administered twice, and reduced (330 mg/m2) doses three times every three to four weeks. She showed a partial response and, for seven months after the beginning of the CBDCA treatment, no progression was seen on the chest X-ray film. It is suggested that there is a need for further phase II studies of CBDCA against non-small cell lung cancer.
一名56岁的家庭主妇在进行胸部X光检查时偶然发现右肺B6区有异常阴影。对该肿块进行经皮肺活检，结果显示为肺腺癌（世界卫生组织分类）。脑部计算机断层扫描（CT）显示有多处脑转移。在进行全脑照射后，于1986年3月7日静脉滴注卡铂（CBDCA）（450 mg/m²）。在最初使用CBDCA治疗三周后，胸部X光片显示原发部位肿瘤大小减小超过50%，此后，每三到四周给予两次相同剂量的CBDCA，并三次给予减量（330 mg/m²）的CBDCA。她出现了部分缓解，在开始使用CBDCA治疗后的七个月里，胸部X光片未显示病情进展。提示有必要进一步开展CBDCA治疗非小细胞肺癌的II期研究。
