天然产物福满菌素和福满菌素酮的合成与生物学研究。
Synthesis and biological study of the phomopsolide and phomopsolidone natural products.
机构信息
Dept. of Chemistry and Chem. Bio., Northeastern Univ., Boston, MA 02115, USA.
出版信息
Chem Commun (Camb). 2020 Nov 4;56(85):12885-12896. doi: 10.1039/d0cc04069j. Epub 2020 Oct 7.
Abstract
The complete history of the syntheses and biological activities of the phomopsolide and phomopsolidone classes of natural products is reviewed. These efforts include the successful synthesis of four of the five phomopsolide natural products, two of the four phomopsolidone natural products and two analogues of phomopsolide E, including the 7-oxa and 7-aza analogues. In addition, the utility of these synthetic efforts to enable the initial structure activity relationship studies for these classes of natural products is also covered.
摘要
本文综述了天然产物福莫司汀和福莫司汀酮类化合物的全合成历史和生物活性。这些工作包括成功合成了五个福莫司汀天然产物中的四个，四个福莫司汀酮天然产物中的两个，以及福莫司汀 E 的两个类似物，包括 7-氧代和 7-氮杂类似物。此外，还介绍了这些合成工作对这些天然产物类别的初始结构活性关系研究的应用。
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