Villoria-Del-Álamo Beatriz, Rojas-Buzo Sergio, García-García Pilar, Corma Avelino
Instituto de Tecnología Química, UPV-CSIC, Universitat Politècnica de València-Consejo Superior de, Investigaciones Científicas, Avenida de los Naranjos s/n, 46022, Valencia, Spain.
Present address: Departamento de Ciencias Farmacéuticas, Facultad de Farmacia, CIETUS, IBSAL, University of Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain.
Chemistry. 2021 Mar 8;27(14):4588-4598. doi: 10.1002/chem.202003752. Epub 2020 Dec 23.
In this work, zirconium-based metal-organic framework Zr-MOF-808-P has been found to be an efficient and versatile catalyst for amide esterification. Comparing with previously reported homogeneous and heterogeneous catalysts, Zr-MOF-808-P can promote the reaction for a wide range of primary, secondary and tertiary amides with n-butanol as nucleophilic agent. Different alcohols have been employed in amide esterification with quantitative yields. Moreover, the catalyst acts as a heterogeneous catalyst and could be reused for at least five consecutive cycles. The amide esterification mechanism has been studied on the Zr-MOF-808 at molecular level by in situ FTIR spectroscopic technique and kinetic study.
在这项工作中，已发现锆基金属有机框架Zr-MOF-808-P是一种用于酰胺酯化反应的高效且通用的催化剂。与先前报道的均相和多相催化剂相比，Zr-MOF-808-P能以正丁醇作为亲核试剂促进多种伯、仲和叔酰胺的反应。在酰胺酯化反应中使用了不同的醇类，并获得了定量产率。此外，该催化剂作为多相催化剂可重复使用至少五个连续循环。通过原位傅里叶变换红外光谱技术和动力学研究，在分子水平上对Zr-MOF-808上的酰胺酯化机理进行了研究。
