Kepes J J, Morantz R A, Dorzab W E
Neurosurgery. 1987 Jul;21(1):81-3. doi: 10.1227/00006123-198707000-00017.
A case of a 73-year-old woman with cerebellar medulloblastoma is described. The patient presented with the classical symptoms and signs of a medulloblastoma, and radiological findings were also consistent with this entity. Nevertheless, because of the patient's advanced age, the possibilities of metastatic tumor involving the cerebellum or a primary cerebellar lymphoma were considered before operation. Pathological examination of the operative specimen showed a classical medulloblastoma with occasional areas of early neuroblastic differentiation. Immunoperoxidase strains for neurofilaments were of help in confirming the neurogenic origin of the neoplastic cells. Although medulloblastomas in adults are not rare, onset after the age of 50 is exceptional, with only two cases on record in patients 65 or older. The present patient seems to be the oldest individual with a cerebellar medulloblastoma thus far reported.
本文描述了一例73岁患小脑髓母细胞瘤的女性病例。该患者表现出髓母细胞瘤的典型症状和体征,影像学检查结果也与此诊断相符。然而,由于患者年龄较大,术前考虑了转移性肿瘤累及小脑或原发性小脑淋巴瘤的可能性。手术标本的病理检查显示为典型的髓母细胞瘤,偶见早期神经母细胞分化区域。神经丝免疫过氧化物酶染色有助于确认肿瘤细胞的神经源性起源。虽然成人髓母细胞瘤并不罕见,但50岁以后发病较为罕见,65岁及以上患者仅有两例记录在案。本患者似乎是迄今为止报道的年龄最大的小脑髓母细胞瘤患者。