Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Institute of Clinical Medicine, University of Oslo, 0318, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, 0310, Oslo, Norway; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, 14186, Stockholm, Sweden.
Cell Calcium. 2020 Dec;92:102289. doi: 10.1016/j.ceca.2020.102289. Epub 2020 Sep 22.
The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca mobilising messenger NAADP and the phosphoinositide PI(3,5)P. Recent work by Arlt et al shows that genetic or chemical inhibition of TPC1 in mice promotes anaphylaxis in vivo through a mechanism involving enhanced endoplasmic reticulum Ca release and secretion in mast cells.
哺乳动物双孔通道 TPC1 和 TPC2 是与病理生理相关的内体溶酶体阳离子通道，受 Ca 动员信使 NAADP 和磷脂酰肌醇 PI(3,5)P 调节。最近 Arlt 等人的工作表明，在小鼠中通过遗传或化学抑制 TPC1 可通过涉及增强肥大细胞内质网 Ca 释放和分泌的机制促进体内过敏反应。
