Shen Hongzhou, Zhi Yin, Zhu Fangxing, Si Jiawen, Shi Jun, Shen Steve Gf
Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine.
National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology.
Dent Mater J. 2021 Jan 31;40(1):191-201. doi: 10.4012/dmj.2019-437. Epub 2020 Oct 7.
In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical alveolar bone reconstruction outcome of BMP2-CPC with those of deproteinized bovine bone (DBB). The animal study indicated that, compared to DBB, which induced the slow ingrowth of new bone, BMP2-CPC induced numerous small growth centers for bone regeneration and facilitated a significant amount of bone regeneration in rabbit calvarial bone defects. Fewer residual graft particles remained in the BMP2-CPC-treated defects than in the DBB-treated defects. The clinical study indicated that BMP2-CPC was similar to DBB in remedying alveolar bone insufficiency and maintaining implant stability. In conclusion, the results of this present study indicate that compared to DBB, BMP2-CPC can significantly enhance in vivo bone regeneration and remodeling in rabbit calvarial bone defects and shows preliminary support on its clinical application in GBR surgeries.
在本研究中，我们提出了一种用于引导骨再生（GBR）的含骨形态发生蛋白2的磷酸钙骨水泥（BMP2-CPC），并将BMP2-CPC的实验性骨修复性能和临床牙槽骨重建结果与脱蛋白牛骨（DBB）的进行了比较。动物研究表明，与诱导新骨缓慢长入的DBB相比，BMP2-CPC诱导了大量小的骨再生生长中心，并促进了兔颅骨缺损处大量的骨再生。与DBB治疗的缺损相比，BMP2-CPC治疗的缺损中残留的移植颗粒更少。临床研究表明，BMP2-CPC在修复牙槽骨不足和维持种植体稳定性方面与DBB相似。总之，本研究结果表明，与DBB相比，BMP2-CPC可显著增强兔颅骨缺损处的体内骨再生和重塑，并为其在GBR手术中的临床应用提供了初步支持。
